| ANDERSSON, Emma, Lenka BRYJOVÁ, Kristin BIRIS, Terry YAMAGUCHI, Ernest ARENAS and Vítězslav BRYJA. Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development. Developmental dynamics. United States: Wiley-Liss, 2010, vol. 2010, No 239, 9 pp. ISSN 1058-8388. |
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@article{877788,
author = {Andersson, Emma and Bryjová, Lenka and Biris, Kristin and Yamaguchi, Terry and Arenas, Ernest and Bryja, Vítězslav},
article_location = {United States},
article_number = {239},
keywords = {Wnt5a; Lrp6; somitogenesis; development},
language = {eng},
issn = {1058-8388},
journal = {Developmental dynamics},
title = {Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development},
volume = {2010},
year = {2010}
}
TY - JOUR
ID - 877788
AU - Andersson, Emma - Bryjová, Lenka - Biris, Kristin - Yamaguchi, Terry - Arenas, Ernest - Bryja, Vítězslav
PY - 2010
TI - Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
JF - Developmental dynamics
VL - 2010
IS - 239
PB - Wiley-Liss
SN - 10588388
KW - Wnt5a
KW - Lrp6
KW - somitogenesis
KW - development
N2 - Lrp6 is generally described as a receptor required for signal transduction in the Wnt/b-catenin pathway. Wnt5a, however, is a Wnt ligand which usually does not activate Wnt/b-catenin but rather activates non-canonical Wnt signaling. Here we describe phenotypes found in Wnt5a/Lrp6 compound mutant mice, including a worsening of individual Wnt5a or Lrp6 loss of function phenotypes. Lrp6 haploinsufficiency in a Wnt5a-/- background caused spina bifida and exacerbated posterior truncation.
ER -
ANDERSSON, Emma, Lenka BRYJOVÁ, Kristin BIRIS, Terry YAMAGUCHI, Ernest ARENAS and Vítězslav BRYJA. Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development. \textit{Developmental dynamics}. United States: Wiley-Liss, 2010, vol.~2010, No~239, 9 pp. ISSN~1058-8388.
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