J 2010

Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

MIKULKOVÁ, Zuzana, Petra PRAKSOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK, Lucie ŠTRAJTOVÁ et. al.

Basic information

Original name

Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

Name in Czech

Chyby v početním zastoupení populace CD8+CD28- supresorových T-lymfocytů u nemocných s diabetem mellitus 1. typu a u pacientů s roztroušenou sklerózou

Authors

MIKULKOVÁ, Zuzana (203 Czech Republic), Petra PRAKSOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Lucie ŠTRAJTOVÁ (203 Czech Republic), Rita PACASOVÁ (203 Czech Republic), Jana BĚLOBRÁDKOVÁ (203 Czech Republic), Petr DÍTĚ (203 Czech Republic, belonging to the institution) and Jaroslav MICHÁLEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Cellular Immunology, United States, Academic Press, 2010, 0008-8749

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.575

RIV identification code

RIV/00216224:14110/10:00040754

Organization unit

Faculty of Medicine

UT WoS

000276599100001

Keywords (in Czech)

autoimunitní onemocnení; T regulační lymfocyty; supresorové buňky; diabetes mellitus

Keywords in English

Type 1 diabetes mellitus; Multiple sclerosis; Autoimmune diseases; Regulatory T-cells; Suppressor cells
Změněno: 18/1/2011 09:10, Mgr. Anna Potáčová, Ph.D.

Abstract

V originále

Type 1 diabetes mellitus and multiple sclerosis are organ-specific autoimmune diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic beta-cells and central nervous system, respectively. Using four-colour flow cytometry, T-lymphocyte populations having an important function in autoimmune processes were analyzed. The observed data demonstrate significant differences among patients with T1D and MS in comparison to healthy individuals.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
NR9355, research and development project
Name: Imunoregulační funkce u dětských pacientů s diabetes mellitus
2B08066, research and development project
Name: Studium léčebných možností diabetes mellitus 1. typu jako geneticky determinované metabolické choroby s využitím nových imunoterapeutických postupů