HROŠŠOVÁ, Dominika, Stjepan ULDRIJAN, Aleš HAMPL, Zbyněk ZDRÁHAL and Štěpánka VAŇÁČOVÁ. Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins. In RNA Club 2009. 2009. ISSN 1214-8598.
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Basic information
Original name Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins
Name in Czech Characterization of a specific 3'- end RNA modification and specific RNA- binding proteins
Authors HROŠŠOVÁ, Dominika, Stjepan ULDRIJAN, Aleš HAMPL, Zbyněk ZDRÁHAL and Štěpánka VAŇÁČOVÁ.
Edition RNA Club 2009, 2009.
Other information
Original language English
Type of outcome Conference abstract
Field of Study Genetics and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Medicine
ISSN 1214-8598
Keywords (in Czech) RNA Club
Keywords in English RNA Club
Tags International impact
Changed by Changed by: prof. Mgr. Štěpánka Vaňáčová, Ph.D., učo 105562. Changed: 9/4/2010 10:57.
Abstract
Modifications of 3' end of mRNAs plays important role in gene expression control. There are two groups of poly (A) polymerases (PAPs) present in the cell: canonical nuclear PAP, and non-canonical PAPs, that differ in the role they play in cell metabolism. There are 7 homologues of non-canonical PAPs in Homo sapiens. At the moment, they are rather poorly characterized. Recently, the largest homolog TUT4 (ZCCHC11) has been shown to play a role in gene expression regulation via the uridylation of specific miRNAs. Several other homologs, have also been shown to poses uridylation activity, in some cases along with the polyadenylation activity.
Abstract (in Czech)
Modifications of 3' end of mRNAs plays important role in gene expression control. There are two groups of poly (A) polymerases (PAPs) present in the cell: canonical nuclear PAP, and non-canonical PAPs, that differ in the role they play in cell metabolism. There are 7 homologues of non-canonical PAPs in Homo sapiens. At the moment, they are rather poorly characterized. Recently, the largest homolog TUT4 (ZCCHC11) has been shown to play a role in gene expression regulation via the uridylation of specific miRNAs. Several other homologs, have also been shown to poses uridylation activity, in some cases along with the polyadenylation activity.
Links
MSM0021622415, plan (intention)Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
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