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@article{879296,
author = {Ryvolová, Markéta and Preisler, Jan and Brabazon,, Dermot and Macka, Miroslav},
article_number = {4},
keywords = {Capillary electrophoresis (CE); Chemiluminescence detection (CLD); Electrochemical detection (ECD); Injection; Laser diode (LD); Lightemitting},
language = {eng},
issn = {0165-9936},
journal = {Trends in Analytical Chemistry},
title = {Portable capillary-based (non-chip) capillary electrophoresis},
volume = {29},
year = {2010}
}
TY - JOUR
ID - 879296
AU - Ryvolová, Markéta - Preisler, Jan - Brabazon,, Dermot - Macka, Miroslav
PY - 2010
TI - Portable capillary-based (non-chip) capillary electrophoresis
JF - Trends in Analytical Chemistry
VL - 29
IS - 4
SP - 339-353
EP - 339-353
SN - 01659936
KW - Capillary electrophoresis (CE)
KW - Chemiluminescence detection (CLD)
KW - Electrochemical detection (ECD)
KW - Injection
KW - Laser diode (LD)
KW - Lightemitting
N2 - Miniaturized, portable instrumentation has been gaining popularity in all areas of analytical chemistry. Capillary electrophoresis (CE), due to its main strengths of high separation efficiency, relatively short analysis time and low consumption of chemicals, is a particularly suitable technique for use in portable analytical instrumentation. In line with the general trend in miniaturization in chemistry utilizing microfluidic chips, the main thrust of portable CE (P-CE) systems development is towards chip-based miniaturized CE. Despite this, capillary-based (non-chip) P-CE systems have certain unmatched advantages, especially in the relative simplicity of the regular cylindrical geometry of the CE capillary, maximal volume-to-surface ratio, no need to design and to fabricate a chip, the low costs of capillary compared to chip, and better performance with some detection techniques. This review presents an overview of the state of the art of P-CE and literature relevant to future developments. We pay particular attention to the development and the potential of miniaturization of functional parts for P-CE. These include components related to sample introduction, separation and detection, which are the key elements in P-CE design. The future of P-CE may be in relatively simple, rugged designs (e.g., using a short piece of capillary fixed to a chip-sized platform on which injection and detection parts can be mounted). Electrochemical detection is well suited for miniaturization, so is probably the most suitable detection technique for P-CE, but optical detection is gaining interest, especially due to miniaturized light sources (e.g., light emitting diodes).
ER -
RYVOLOVÁ, Markéta, Jan PREISLER, Dermot BRABAZON, and Miroslav MACKA. Portable capillary-based (non-chip) capillary electrophoresis. \textit{Trends in Analytical Chemistry}. 2010, vol.~29, No~4, p.~339-353, 14 pp. ISSN~0165-9936.
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