| ŠTEFANČÍKOVÁ, Lenka, Mojmír MOULIS, Pavel FABIAN, Barbora RAVČUKOVÁ, Ingrid VÁŠOVÁ, Jan MUŽÍK, Jitka MALČÍKOVÁ, Iva FALKOVÁ, Jana SLOVÁČKOVÁ and Jana ŠMARDOVÁ. Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma. International Journal of Oncology. Athens, Greece: International Center for Cancer Research, 2010, vol. 36, No 3, p. 699-706. ISSN 1019-6439. Available from: https://dx.doi.org/10.3892/ijo_00000545. |
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@article{879386,
author = {Štefančíková, Lenka and Moulis, Mojmír and Fabian, Pavel and Ravčuková, Barbora and Vášová, Ingrid and Mužík, Jan and Malčíková, Jitka and Falková, Iva and Slováčková, Jana and Šmardová, Jana},
article_location = {Athens, Greece},
article_number = {3},
doi = {http://dx.doi.org/10.3892/ijo_00000545},
keywords = {mantle cell lymphoma; MCL pathogenesis},
language = {eng},
issn = {1019-6439},
journal = {International Journal of Oncology},
title = {Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma},
volume = {36},
year = {2010}
}
TY - JOUR
ID - 879386
AU - Štefančíková, Lenka - Moulis, Mojmír - Fabian, Pavel - Ravčuková, Barbora - Vášová, Ingrid - Mužík, Jan - Malčíková, Jitka - Falková, Iva - Slováčková, Jana - Šmardová, Jana
PY - 2010
TI - Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma
JF - International Journal of Oncology
VL - 36
IS - 3
SP - 699-706
EP - 699-706
PB - International Center for Cancer Research
SN - 10196439
KW - mantle cell lymphoma
KW - MCL pathogenesis
N2 - Mantle cell lymphoma (MCL) is typified by translocation t(11;14)(q13;q32) causing upregulation of cyclin D1 and deregulation of cell cycle. The cyclin D1 activation plays a critical role in MCL pathogenesis but additional oncogenic events, such as abberations of the ARF/MDM2/p53 pathway are also necessary for progression of the disease. We analyzed the p53 tumor suppressor in tumor tissue of 33 patients with MCL. The p53 status was determined by functional analyses in yeast (FASAY) and by cDNA sequencing. The level of the p53 protein was assessed by immunoblotting. Loss of the p53-specific locus 17p13.3 was detected by FISH. Mutations in the p53 gene were detected in nine samples and they included eight missense mutations and one short deletion causing frame shift and premature stop codon formation in position 169. This mutation was associated with mRNA decay as revealed by sequencing of the p53 gDNA. All eight missense mutations were manifested by accumulation of the p53 protein in nuclei of tumor cells and three of them exhibited loss of the p-53 specific locus 17p13.3. The p53 mutations were shown to be a negative prognostic marker in MCL.
ER -
ŠTEFANČÍKOVÁ, Lenka, Mojmír MOULIS, Pavel FABIAN, Barbora RAVČUKOVÁ, Ingrid VÁŠOVÁ, Jan MUŽÍK, Jitka MALČÍKOVÁ, Iva FALKOVÁ, Jana SLOVÁČKOVÁ and Jana ŠMARDOVÁ. Loss of the p53 tumor suppressor activity is associated with negative prognosis of mantle cell lymphoma. \textit{International Journal of Oncology}. Athens, Greece: International Center for Cancer Research, 2010, vol.~36, No~3, p.~699-706. ISSN~1019-6439. Available from: https://dx.doi.org/10.3892/ijo\_{}00000545.
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