Modulation of cell proliferation and differentiation of human
lung carcinoma cells by the interferon-alpha

J 2009

Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha

KREJČOVÁ, Daniela, Jiřina PROCHÁZKOVÁ, Jiří PACHERNÍK and Lukáš KUBALA

Basic information

Original name

Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha

Authors

KREJČOVÁ, Daniela (203 Czech Republic), Jiřina PROCHÁZKOVÁ (203 Czech Republic), Jiří PACHERNÍK (203 Czech Republic) and Lukáš KUBALA (203 Czech Republic, guarantor)

Edition

GENERAL PHYSIOLOGY AND BIOPHYSICS, 2009, 0231-5882

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.741

RIV identification code

RIV/00216224:14110/09:00028863

Organization unit

Faculty of Medicine

UT WoS

000272335700010

Keywords in English

Non-small cell lung cancer; ABC transporter proteins; Cell cycle; Interferons

Abstract

V originále

Interferon alpha (IFN-alpha), an important physiological immunomodulator, possesses direct cytotoxic and cytostatic effects on tumour cells, antiangiogenic effects, and activates anti-tumour immunity. Herein the human lung carcinoma cell line A549, a model of NSCLC in vitro, was used to pursue the effect of IFN-alpha on A549 cell proliferation and differentiation together with the effect on protein expression and activity of three ATP-transporters mediating multi-drug resistance (MDR). IFN-alpha significantly inhibited the proliferation of A549 cells which was not connected with arrest in a particular cell cycle phase. IFN-alpha-mediated differentiation of A549 was observed based on an increase in alkaline phosphatase activity. Simultaneously, IFN-alpha increased the expression and activity of ATP-transporters mediating MDR. The IFN-alpha down-regulation of NSCLC cell proliferation was accompanied by a potential of cells to exclude potential therapeutic substances such as chemotherapeutic agents.

Citovat

KREJČOVÁ, Daniela, Jiřina PROCHÁZKOVÁ, Jiří PACHERNÍK and Lukáš KUBALA. Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha. GENERAL PHYSIOLOGY AND BIOPHYSICS. 2009, vol. 28, No 3, 8 pp. ISSN 0231-5882.

@article{879427,
   author = {Krejčová, Daniela and Procházková, Jiřina and Pacherník, Jiří and Kubala, Lukáš},
   article_number = {3},
   keywords = {Non-small cell lung cancer; ABC transporter proteins; Cell cycle; Interferons},
   language = {eng},
   issn = {0231-5882},
   journal = {GENERAL PHYSIOLOGY AND BIOPHYSICS},
   title = {Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha},
   volume = {28},
   year = {2009}
}

TY  - JOUR
ID  - 879427
AU  - Krejčová, Daniela - Procházková, Jiřina - Pacherník, Jiří - Kubala, Lukáš
PY  - 2009
TI  - Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha
JF  - GENERAL PHYSIOLOGY AND BIOPHYSICS
VL  - 28
IS  - 3
SN  - 02315882
KW  - Non-small cell lung cancer
KW  - ABC transporter proteins
KW  - Cell cycle
KW  - Interferons
N2  - Interferon alpha (IFN-alpha), an important physiological immunomodulator, possesses direct cytotoxic and cytostatic effects on tumour cells, antiangiogenic effects, and activates anti-tumour immunity. Herein the human lung carcinoma cell line A549, a model of NSCLC in vitro, was used to pursue the effect of IFN-alpha on A549 cell proliferation and differentiation together with the effect on protein expression and activity of three ATP-transporters mediating multi-drug resistance (MDR). IFN-alpha significantly inhibited the proliferation of A549 cells which was not connected with arrest in a particular cell cycle phase. IFN-alpha-mediated differentiation of A549 was observed based on an increase in alkaline phosphatase activity. Simultaneously, IFN-alpha increased the expression and activity of ATP-transporters mediating MDR. The IFN-alpha down-regulation of NSCLC cell proliferation was accompanied by a potential of cells to exclude potential therapeutic substances such as chemotherapeutic agents.
ER  -

KREJČOVÁ, Daniela, Jiřina PROCHÁZKOVÁ, Jiří PACHERNÍK and Lukáš KUBALA. Modulation of cell proliferation and differentiation of human lung carcinoma cells by the interferon-alpha. \textit{GENERAL PHYSIOLOGY AND BIOPHYSICS}. 2009, vol.~28, No~3, 8 pp. ISSN~0231-5882.

Detailed Information on Publication Record