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@proceedings{881115, author = {Knopfová, Lucia and Trčka, Filip and Beneš, Petr and Šmarda, Jan}, booktitle = {The 6th symposium and workshop on molecular pathology and histo(cyto)chemistry}, keywords = {c-Myb; invasion; migration; breast carcinoma}, language = {eng}, isbn = {978-80-87327-07-4}, title = {c-Myb promotes motility and invasion of breast cancer cells}, year = {2010} }
TY - CONF ID - 881115 AU - Knopfová, Lucia - Trčka, Filip - Beneš, Petr - Šmarda, Jan PY - 2010 TI - c-Myb promotes motility and invasion of breast cancer cells SN - 9788087327074 KW - c-Myb KW - invasion KW - migration KW - breast carcinoma N2 - The aim of this study was to assess the role of the c-Myb protein in control of invasion of breast cancer cells. MDA-MB-231 breast cancer cells were transfected with the c-Myb coding cDNA to prepare MDA-MB-231MYBup derivatives. The effects of c-Myb overexpression on migration and invasion capacity of these cells were assessed. MDA-MB-231MYBup cells were significantly more active in both motility and invasion than controls. In order to reveal dynamics of these processes, we performed real-time analysis of cell migration and invasion using the xCELLigence RT-CA system. This analysis clearly confirmed increased invasive capacity of MDA-MB-231MYBup cells compared to controls. To address the mechanism of c-Myb-enhanced breast cancer cell invasion, we examined the role of c-Myb in control of expression and activity of some of the proteases involved in degradation of extracellular matrix. We found that c-Myb increased production of cathepsin D and matrix metalloproteinases in MDA-MB-231MYBup cells. ER -
KNOPFOVÁ, Lucia, Filip TRČKA, Petr BENEŠ a Jan ŠMARDA. c-Myb promotes motility and invasion of breast cancer cells. In \textit{The 6th symposium and workshop on molecular pathology and histo(cyto)chemistry}. 2010. ISBN~978-80-87327-07-4.
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