| CHLAPEK, Petr, Martina RÉDOVÁ, Karel ZITTERBART, Markéta HERMANOVÁ, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study. Journal of Experimental and Clinical Cancer Research. London: BioMed Central Ltd., 2010, roč. 29, č. 45, 8 s. ISSN 1756-9966. |
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@article{883375,
author = {Chlapek, Petr and Rédová, Martina and Zitterbart, Karel and Hermanová, Markéta and Štěrba, Jaroslav and Veselská, Renata},
article_location = {London},
article_number = {45},
keywords = {neuroblastoma; expression profiling; retinoids; ATRA; caffeic acid; celecoxib},
language = {eng},
issn = {1756-9966},
journal = {Journal of Experimental and Clinical Cancer Research},
title = {Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study.},
volume = {29},
year = {2010}
}
TY - JOUR
ID - 883375
AU - Chlapek, Petr - Rédová, Martina - Zitterbart, Karel - Hermanová, Markéta - Štěrba, Jaroslav - Veselská, Renata
PY - 2010
TI - Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study.
JF - Journal of Experimental and Clinical Cancer Research
VL - 29
IS - 45
PB - BioMed Central Ltd.
SN - 17569966
KW - neuroblastoma
KW - expression profiling
KW - retinoids
KW - ATRA
KW - caffeic acid
KW - celecoxib
N2 - Expression profiling of 440 cancer-related genes in two neuroblastoma cell lines, SK-N-BE(2) a SH-SY5Y, after combined treatment with all-trans retinoic acid (ATRA) and LOX/COX inhibitors was performed. Cluster analyses of the changes in gene expression showed the concentration-dependent increase in genes known to be involved in the process of retinoid-induced neuronal differentiation, especially in cytoskeleton remodeling. These changes were detected in both cell lines, and they were independent of the type of specific inhibitors, suggesting a common mechanism of ATRA-induced differentiation enhancement.
ER -
CHLAPEK, Petr, Martina RÉDOVÁ, Karel ZITTERBART, Markéta HERMANOVÁ, Jaroslav ŠTĚRBA a Renata VESELSKÁ. Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: An expression profiling study. \textit{Journal of Experimental and Clinical Cancer Research}. London: BioMed Central Ltd., 2010, roč.~29, č.~45, 8 s. ISSN~1756-9966.
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