Detailed Information on Publication Record
2010
Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
KŘEN, Leoš, Katarína MÚČKOVÁ, Eva LŽIČAŘOVÁ, Marek SOVA, Václav VYBÍHAL et. al.Basic information
Original name
Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?
Name in Czech
Produkce neklasických imunomodulačních molekul HLA-G a HLA-E tumor infiltrujícími ameboidními mikrogliemi/makrofágy u glioblastomu: Role přirozené imunity?
Authors
KŘEN, Leoš (203 Czech Republic, guarantor, belonging to the institution), Katarína MÚČKOVÁ (703 Slovakia, belonging to the institution), Eva LŽIČAŘOVÁ (203 Czech Republic), Marek SOVA (203 Czech Republic), Václav VYBÍHAL (203 Czech Republic), Tomáš SVOBODA (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Zdenka KŘENOVÁ (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic, belonging to the institution)
Edition
Journal of Neuroimmunology, Netherlands, Elsevier/North-Holland, 2010, 0165-5728
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Netherlands
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.901
RIV identification code
RIV/00216224:14110/10:00051367
Organization unit
Faculty of Medicine
UT WoS
000276469900018
Keywords (in Czech)
HLA-E; HLA-G; Microglie; Glioblastom
Keywords in English
HLA-E; HLA-G; Microglia; Glioblastoma
Tags
International impact
Změněno: 12/4/2012 15:01, Mgr. Michal Petr
V originále
The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of FILA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.
In Czech
Možná úloha neklasických imunomodulačních molekul HLA-G a HLA-E v protinádorové odpovědi a u glioblastomů není doposud dostatečně popsána. V této práci jsme se zaměřili na stanovení exprese těchto znaků aktivovanými tumor infiltrujícími mikrogliemi/makrofágy. Tato exprese byla zjištěna u většiny sledovaných glioblastomů. Pro vysvětlení podrobnějších mechanismů protinádorové imunity jsou nezbytné další studie.