| FOLTYNOVÁ, Pavla, Jarmila NAVRÁTILOVÁ, Ondřej PEŠ, Tomáš VACULOVIČ, Viktor KANICKÝ, Jan ŠMARDA and Jan PREISLER. Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells. Journal of Analytical Atomic Spectrometry. ENGLAND: ROYAL SOC CHEMISTRY, 2010, vol. 25, No 5, p. 662-668. ISSN 0267-9477. |
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@article{883989,
author = {Foltynová, Pavla and Navrátilová, Jarmila and Peš, Ondřej and Vaculovič, Tomáš and Kanický, Viktor and Šmarda, Jan and Preisler, Jan},
article_location = {ENGLAND},
article_number = {5},
keywords = {ATOMIC-ABSORPTION-SPECTROMETRY; LA-ICP-MS; CAPILLARY-ELECTROPHORESIS; CALIBRATION STRATEGY; GEL-ELECTROPHORESIS; PROTEASOME ACTIVITY; BIOLOGICAL SAMPLES; TRACE-METALS; ABLATION; DISULFIRAM},
language = {eng},
issn = {0267-9477},
journal = {Journal of Analytical Atomic Spectrometry},
title = {Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells},
volume = {25},
year = {2010}
}
TY - JOUR
ID - 883989
AU - Foltynová, Pavla - Navrátilová, Jarmila - Peš, Ondřej - Vaculovič, Tomáš - Kanický, Viktor - Šmarda, Jan - Preisler, Jan
PY - 2010
TI - Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells
JF - Journal of Analytical Atomic Spectrometry
VL - 25
IS - 5
SP - 662-668
EP - 662-668
PB - ROYAL SOC CHEMISTRY
SN - 02679477
KW - ATOMIC-ABSORPTION-SPECTROMETRY
KW - LA-ICP-MS
KW - CAPILLARY-ELECTROPHORESIS
KW - CALIBRATION STRATEGY
KW - GEL-ELECTROPHORESIS
KW - PROTEASOME ACTIVITY
KW - BIOLOGICAL SAMPLES
KW - TRACE-METALS
KW - ABLATION
KW - DISULFIRAM
N2 - This work presents a detailed characterization of substrate-assisted laser desorption inductively coupled plasma mass spectrometry (SALD ICP-MS), a new approach in the determination of trace elements in submicrolitre volumes. SALD ICP-MS allows quantitative analysis of metals in liquid samples with defined volumes deposited onto an absorbing substrate due to complete sample desorption at relatively low laser power density. Analysis of model samples of Cu(II) showed a constant signal over a wide range of laser power density, an independence of signal on desorption modes and a wide linear dynamic range. SALD ICP-MS with its limit of detection for copper below 26 fg in submicrolitre samples was successfully applied to investigate cytotoxic effects of disulfiram in human myeloid leukemia cells U937 depending on intracellular levels of copper.
ER -
FOLTYNOVÁ, Pavla, Jarmila NAVRÁTILOVÁ, Ondřej PEŠ, Tomáš VACULOVIČ, Viktor KANICKÝ, Jan ŠMARDA and Jan PREISLER. Substrate-assisted laser desorption inductively-coupled plasma mass spectrometry for determination of copper in myeloid leukemia cells. \textit{Journal of Analytical Atomic Spectrometry}. ENGLAND: ROYAL SOC CHEMISTRY, 2010, vol.~25, No~5, p.~662-668. ISSN~0267-9477.
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