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@article{887029,
author = {Holochová, Pavla and Růžičková, Vladislava and Pantůček, Roman and Petráš, Petr and Janisch, Roman and Doškař, Jiří},
article_location = {France},
article_number = {4},
keywords = {Staphylococcus aureus; Exfoliative toxin A; Phage conversion; Virion proteins; Genome sequences},
language = {eng},
issn = {0923-2508},
journal = {Research in Microbiology},
title = {Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in Czech Republic},
url = {http://dx.doi.org/10.1016/j.resmic.2010.03.008},
volume = {161},
year = {2010}
}
TY - JOUR
ID - 887029
AU - Holochová, Pavla - Růžičková, Vladislava - Pantůček, Roman - Petráš, Petr - Janisch, Roman - Doškař, Jiří
PY - 2010
TI - Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in Czech Republic
JF - Research in Microbiology
VL - 161
IS - 4
SP - 260-267
EP - 260-267
PB - Elsevier Masson SAS.
SN - 09232508
KW - Staphylococcus aureus
KW - Exfoliative toxin A
KW - Phage conversion
KW - Virion proteins
KW - Genome sequences
UR - http://dx.doi.org/10.1016/j.resmic.2010.03.008
N2 - We have isolated and characterized two distinct types of exfoliative toxin A (ETA) converting bacteriophages originated from the S. aureus strains responsible for massive outbreaks of pemphigus neonatorum in the Czech Republic. Three induced phages designated as phiB531, phiB557 and phiB122, were found to be capable of transferring the eta gene into the prophageless non-toxigenic S. aureus strain, and converting it into an ETA producer. Comparisons of the phage sequences derived from 12 selected genes and 2 genomic segments (polymorphic P2 and conserved C4) revealed that phiB531 and phiB557 were identical each other, but phiB122 differed from them in five gene sequences, the xis gene content, and virion protein profile. Thus, phiB122 represents a new type of still undescribed ETA converting phage. This study has highlighted not only the conclusive genomic diversity of eta gene-positive phages but also their virulence implications in impetigo S. aureus strains.
ER -
HOLOCHOVÁ, Pavla, Vladislava RŮŽIČKOVÁ, Roman PANTŮČEK, Petr PETRÁŠ, Roman JANISCH a Jiří DOŠKAŘ. Genomic diversity of two lineages of exfoliative toxin A-converting phages predominating in Staphylococcus aureus strains in Czech Republic. \textit{Research in Microbiology}. France: Elsevier Masson SAS., roč.~161, č.~4, s.~260-267. ISSN~0923-2508. 2010.
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