IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen

ADAM, Zdeněk, Marta KREJČÍ, Luděk POUR, Josef FEIT, Tomáš BÜCHLER and Roman HÁJEK. IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen. Wiener klinische Wochenschrift. Wien: Springer, 2010, vol. 122, 9-10, p. 311-314. ISSN 0043-5325.

Basic information

• Original name: IgA pemphigus associated with monoclonal gammopathy completely resolved after achievement of complete remission of multiple myeloma with bortezomib, cyclophosphamide and dexamethasone regimen
• Name in Czech: Vymizení IgA pemphigus spojeného s monoklonální gamapatií po dosažení kompletní remise mnohočetného myelomu po léčbě režimem VCD
• Authors: ADAM, Zdeněk (203 Czech Republic, guarantor), Marta KREJČÍ (203 Czech Republic), Luděk POUR (203 Czech Republic), Josef FEIT (203 Czech Republic), Tomáš BÜCHLER (703 Slovakia) and Roman HÁJEK (203 Czech Republic).
• Edition: Wiener klinische Wochenschrift, Wien, Springer, 2010, 0043-5325.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 0.747
• RIV identification code: RIV/00216224:14110/10:00044190
• Organization unit: Faculty of Medicine
• UT WoS: 000278954200008
• Keywords (in Czech): IgA pemphigus; bortezomib; rituximab; monoklonální gamapatie
• Keywords in English: IgA pemphigus;bortezomib; rituximab; monoclonal gammopathy

Abstract

Monoclonal gammopathy-associated IgA pemphigus is a debilitating skin disorder with inconsistent response to treatment. A 61-year-old woman with IgA pemphigus and monoclonal gammopathy of unknown significance had been treated with bortezomib, cyclophosphamide and dexamethasone regimen, which resulted in complete and durable remission of multiple myeloma and IgA pemphigus. This suggests that bortezomib-based therapy is useful for the treatment of the rare dermatologic disorder associated with IgA gammopathy.

Abstract (in Czech)

V publikaci je popsán případ 61 leté pecientky s IgA pemfigem a monoklonální gamapatií a výslekdy léčby režimem bortezomib, cyclophosphamid a dexamethasone, po němž došlo k úplnému vymyzení IgA pemfingu.

Links

• LC06027, research and development project: Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)

Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group

• MSM0021622434, plan (intention): Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií

Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies