Matrix Metalloproteinase-2 Promoter Genotype as a Marker of
Cutaneous T-Cell Lymphoma Early Stage

J 2010

Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Nečas MIROSLAV a Vladimír VAŠKŮ

Základní údaje

Originální název

Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

Název česky

Genotyp v promotoru matrix metaloproteinázy-2 jako marker časného stadia kožního T-lymfomu

Autoři

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Nečas MIROSLAV a Vladimír VAŠKŮ

Vydání

Journal of Biomedicine and Biotechnology, USA, New York, Hindawi Publishing Corporation, 2010, 1110-7243

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.230

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14110/10:00044289

Organizační jednotka

Lékařská fakulta

UT WoS

000280912300001

Klíčová slova česky

kožní T-lymfom; mycosis fungoides; matrix metaloproteináza 2; promotor; genotyp

Klíčová slova anglicky

cutaneous T-cell lymphoma; mycosis fungoides; matrix metalloproteinase 2; promoter; genotype

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 1. 2011 08:22, prof. MUDr. Anna Vašků, CSc.

Anotace

ORIG CZ

V originále

The aim of the study was to investigate the DNA polymorphic genotype in MMP2 promoter gene as a potential candidate region for the development of the cutaneous T cell lymphoma (CTCL) andor its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls. The three selected polymorphisms in the promoter of MMP2 gene were determined using the PCR based methodology with RFLP. In our cohort, the associated GGCCTT MMP2 promoter genotype was highly significantly more frequent in CTCL Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.

Česky

Cílem studie bylo zhodnotit potenciál tří vybraných SNP v promotoru genu pro MMP2 a jejich složených genotypů ve vztahu k různých stádiím onemocnění kožním T-lymfomem. S dostatečnou senzitivitou a psecifitou jsme našli DNA marker (GGTTCC genotyp v genu pro MMP-2) pro rozlišení mezi parapsoriázou a 1. stádiem kožního T-lymfomu.

Citovat

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Nečas MIROSLAV a Vladimír VAŠKŮ. Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage. Journal of Biomedicine and Biotechnology. USA, New York: Hindawi Publishing Corporation, 2010, roč. 2010, 2010:80590, s. 1-5. ISSN 1110-7243.

@article{890561,
   author = {Vašků, Anna and Bienertová Vašků, Julie and Miroslav, Nečas and Vašků, Vladimír},
   article_location = {USA, New York},
   article_number = {2010:80590},
   keywords = {cutaneous T-cell lymphoma; mycosis fungoides; matrix metalloproteinase 2; promoter; genotype},
   language = {eng},
   issn = {1110-7243},
   journal = {Journal of Biomedicine and Biotechnology},
   title = {Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage},
   volume = {2010},
   year = {2010}
}

TY  - JOUR
ID  - 890561
AU  - Vašků, Anna - Bienertová Vašků, Julie - Miroslav, Nečas - Vašků, Vladimír
PY  - 2010
TI  - Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage
JF  - Journal of Biomedicine and Biotechnology
VL  - 2010
IS  - 2010:80590
SP  - 1-5
EP  - 1-5
PB  - Hindawi Publishing Corporation
SN  - 11107243
KW  - cutaneous T-cell lymphoma
KW  - mycosis fungoides
KW  - matrix metalloproteinase 2
KW  - promoter
KW  - genotype
N2  - The aim of the study was to investigate the DNA polymorphic genotype in MMP2 promoter gene as a potential candidate region for the development of the cutaneous T cell lymphoma (CTCL) andor its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls. The three selected polymorphisms in the promoter of MMP2 gene were determined using the PCR based methodology with RFLP. In our cohort, the associated GGCCTT MMP2 promoter genotype was highly significantly more frequent in CTCL Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.
ER  -

VAŠKŮ, Anna; Julie BIENERTOVÁ VAŠKŮ; Nečas MIROSLAV a Vladimír VAŠKŮ. Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage. \textit{Journal of Biomedicine and Biotechnology}. USA, New York: Hindawi Publishing Corporation, 2010, roč.~2010, 2010:80590, s.~1-5. ISSN~1110-7243.

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