Matrix Metalloproteinase-2 Promoter Genotype as a Marker of
Cutaneous T-Cell Lymphoma Early Stage

J 2010

Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Nečas MIROSLAV and Vladimír VAŠKŮ

Basic information

Original name

Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

Name in Czech

Genotyp v promotoru matrix metaloproteinázy-2 jako marker časného stadia kožního T-lymfomu

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Nečas MIROSLAV (203 Czech Republic) and Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

Journal of Biomedicine and Biotechnology, USA, New York, Hindawi Publishing Corporation, 2010, 1110-7243

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.230

RIV identification code

RIV/00216224:14110/10:00044289

Organization unit

Faculty of Medicine

UT WoS

000280912300001

Keywords (in Czech)

kožní T-lymfom; mycosis fungoides; matrix metaloproteináza 2; promotor; genotyp

Keywords in English

cutaneous T-cell lymphoma; mycosis fungoides; matrix metalloproteinase 2; promoter; genotype

Abstract

ORIG CZ

V originále

The aim of the study was to investigate the DNA polymorphic genotype in MMP2 promoter gene as a potential candidate region for the development of the cutaneous T cell lymphoma (CTCL) andor its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls. The three selected polymorphisms in the promoter of MMP2 gene were determined using the PCR based methodology with RFLP. In our cohort, the associated GGCCTT MMP2 promoter genotype was highly significantly more frequent in CTCL Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.

In Czech

Cílem studie bylo zhodnotit potenciál tří vybraných SNP v promotoru genu pro MMP2 a jejich složených genotypů ve vztahu k různých stádiím onemocnění kožním T-lymfomem. S dostatečnou senzitivitou a psecifitou jsme našli DNA marker (GGTTCC genotyp v genu pro MMP-2) pro rozlišení mezi parapsoriázou a 1. stádiem kožního T-lymfomu.

Citovat

VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Nečas MIROSLAV and Vladimír VAŠKŮ. Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage. Journal of Biomedicine and Biotechnology. USA, New York: Hindawi Publishing Corporation, 2010, vol. 2010, 2010:80590, p. 1-5. ISSN 1110-7243.

@article{890561,
   author = {Vašků, Anna and Bienertová Vašků, Julie and Miroslav, Nečas and Vašků, Vladimír},
   article_location = {USA, New York},
   article_number = {2010:80590},
   keywords = {cutaneous T-cell lymphoma; mycosis fungoides; matrix metalloproteinase 2; promoter; genotype},
   language = {eng},
   issn = {1110-7243},
   journal = {Journal of Biomedicine and Biotechnology},
   title = {Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage},
   volume = {2010},
   year = {2010}
}

TY  - JOUR
ID  - 890561
AU  - Vašků, Anna - Bienertová Vašků, Julie - Miroslav, Nečas - Vašků, Vladimír
PY  - 2010
TI  - Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage
JF  - Journal of Biomedicine and Biotechnology
VL  - 2010
IS  - 2010:80590
SP  - 1-5
EP  - 1-5
PB  - Hindawi Publishing Corporation
SN  - 11107243
KW  - cutaneous T-cell lymphoma
KW  - mycosis fungoides
KW  - matrix metalloproteinase 2
KW  - promoter
KW  - genotype
N2  - The aim of the study was to investigate the DNA polymorphic genotype in MMP2 promoter gene as a potential candidate region for the development of the cutaneous T cell lymphoma (CTCL) andor its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls. The three selected polymorphisms in the promoter of MMP2 gene were determined using the PCR based methodology with RFLP. In our cohort, the associated GGCCTT MMP2 promoter genotype was highly significantly more frequent in CTCL Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.
ER  -

VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Nečas MIROSLAV and Vladimír VAŠKŮ. Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage. \textit{Journal of Biomedicine and Biotechnology}. USA, New York: Hindawi Publishing Corporation, 2010, vol.~2010, 2010:80590, p.~1-5. ISSN~1110-7243.

Detailed Information on Publication Record