VAŠKŮ, Anna, Julie BIENERTOVÁ VAŠKŮ, Nečas MIROSLAV and Vladimír VAŠKŮ. Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage. Journal of Biomedicine and Biotechnology. USA, New York: Hindawi Publishing Corporation, 2010, vol. 2010, 2010:80590, p. 1-5. ISSN 1110-7243.
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Basic information
Original name Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage
Name in Czech Genotyp v promotoru matrix metaloproteinázy-2 jako marker časného stadia kožního T-lymfomu
Authors VAŠKŮ, Anna (203 Czech Republic, guarantor, belonging to the institution), Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, belonging to the institution), Nečas MIROSLAV (203 Czech Republic) and Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition Journal of Biomedicine and Biotechnology, USA, New York, Hindawi Publishing Corporation, 2010, 1110-7243.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30216 Dermatology and venereal diseases
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.230
RIV identification code RIV/00216224:14110/10:00044289
Organization unit Faculty of Medicine
UT WoS 000280912300001
Keywords (in Czech) kožní T-lymfom; mycosis fungoides; matrix metaloproteináza 2; promotor; genotyp
Keywords in English cutaneous T-cell lymphoma; mycosis fungoides; matrix metalloproteinase 2; promoter; genotype
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Anna Vašků, CSc., učo 122. Changed: 20/1/2011 08:22.
Abstract
The aim of the study was to investigate the DNA polymorphic genotype in MMP2 promoter gene as a potential candidate region for the development of the cutaneous T cell lymphoma (CTCL) andor its progression. A total of 89 Czech patients with CTCL (including 23 patients with large plaque parapsoriasis) were compared to 198 controls. The three selected polymorphisms in the promoter of MMP2 gene were determined using the PCR based methodology with RFLP. In our cohort, the associated GGCCTT MMP2 promoter genotype was highly significantly more frequent in CTCL Ia stage patients compared to patients with parapsoriasis, the tests having high sensitivity and specificity (78%, 83%, resp.). To conclude, use of associated MMP2 promoter genotype as a DNA marker might make it possible to distinguish between the patients with parapsoriasis and those with CTCL stage Ia, which could substantially improve possibilities of clinical diagnostics, therapy design, and prognosis of this serious condition in the early stages.
Abstract (in Czech)
Cílem studie bylo zhodnotit potenciál tří vybraných SNP v promotoru genu pro MMP2 a jejich složených genotypů ve vztahu k různých stádiím onemocnění kožním T-lymfomem. S dostatečnou senzitivitou a psecifitou jsme našli DNA marker (GGTTCC genotyp v genu pro MMP-2) pro rozlišení mezi parapsoriázou a 1. stádiem kožního T-lymfomu.
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