| ŠMEJKAL, Karel, Jana SVAČINOVÁ, Tereza ŠLAPETOVÁ, Kristýna SCHNEIDEROVÁ, Stefano DALL'ACQUA, Gabbriela INNOCENTI, Veronika ZÁVALOVÁ, Peter KOLLÁR, Stanislav CHUDÍK, Radek MAREK, Ondřej JULÍNEK, Marie URBANOVÁ, Murat KARTAL, Marek CSOLLEI and Karel DOLEŽAL. Cytotoxic Activities of Several Geranyl-Substituted Flavanones. Journal of Natural Products. Americal Chemical Society, 2010, vol. 73, No 4, p. 568-572. ISSN 0163-3864. |
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@article{891276,
author = {Šmejkal, Karel and Svačinová, Jana and Šlapetová, Tereza and Schneiderová, Kristýna and Dall'Acqua, Stefano and Innocenti, Gabbriela and Závalová, Veronika and Kollár, Peter and Chudík, Stanislav and Marek, Radek and Julínek, Ondřej and Urbanová, Marie and Kartal, Murat and Csollei, Marek and Doležal, Karel},
article_number = {4},
keywords = {cytotoxic; flavanones; Paulownia tomentosa; Morus alba; geranyl substitution},
language = {eng},
issn = {0163-3864},
journal = {Journal of Natural Products},
title = {Cytotoxic Activities of Several Geranyl-Substituted Flavanones},
url = {http://pubs.acs.org/doi/abs/10.1021/np900681y},
volume = {73},
year = {2010}
}
TY - JOUR
ID - 891276
AU - Šmejkal, Karel - Svačinová, Jana - Šlapetová, Tereza - Schneiderová, Kristýna - Dall'Acqua, Stefano - Innocenti, Gabbriela - Závalová, Veronika - Kollár, Peter - Chudík, Stanislav - Marek, Radek - Julínek, Ondřej - Urbanová, Marie - Kartal, Murat - Csollei, Marek - Doležal, Karel
PY - 2010
TI - Cytotoxic Activities of Several Geranyl-Substituted Flavanones
JF - Journal of Natural Products
VL - 73
IS - 4
SP - 568-572
EP - 568-572
PB - Americal Chemical Society
SN - 01633864
KW - cytotoxic
KW - flavanones
KW - Paulownia tomentosa
KW - Morus alba
KW - geranyl substitution
UR - http://pubs.acs.org/doi/abs/10.1021/np900681y
N2 - Nine geranylated flavanones isolated from the fruits of Paulownia tomentosa and two from the roots of Morus alba were examined for cytotoxicity to selected human cancer cell lines and normal human fibroblasts. Cytotoxicity was determined in vitro using a calcein AM cytotoxicity assay. Cytotoxicity for the THP-1 monocytic leukemia cell line was tested using erythrosin B cell staining. The geranylated compounds tested were compared with the known simple flavanone standards taxifolin, naringenin, and hesperetin and with the standard anticancer drugs olomoucine II, diaziquone, and oxaliplatin and the antineoplastic compound camptothecin, and showed different levels of cytotoxicity. The effects of structural changes on cytotoxic activity, including geranyl substitution of the flavanone skeleton and the oxidation pattern of ring B of the flavanones, are discussed.
ER -
ŠMEJKAL, Karel, Jana SVAČINOVÁ, Tereza ŠLAPETOVÁ, Kristýna SCHNEIDEROVÁ, Stefano DALL'ACQUA, Gabbriela INNOCENTI, Veronika ZÁVALOVÁ, Peter KOLLÁR, Stanislav CHUDÍK, Radek MAREK, Ondřej JULÍNEK, Marie URBANOVÁ, Murat KARTAL, Marek CSOLLEI and Karel DOLEŽAL. Cytotoxic Activities of Several Geranyl-Substituted Flavanones. \textit{Journal of Natural Products}. Americal Chemical Society, 2010, vol.~73, No~4, p.~568-572. ISSN~0163-3864.
|
