High perioperative level of oxidative stress as a prognostic
tool for identifying patients with a high risk of recurrence of
head and neck squamous cell carcinoma

J 2010

High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma

SALZMAN, Richard, Lukáš PÁCAL, Kateřina KAŇKOVÁ, Josef TOMANDL, Zuzana HORÁKOVÁ et. al.

Basic information

Original name

High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma

Authors

SALZMAN, Richard (703 Slovakia), Lukáš PÁCAL (203 Czech Republic, guarantor, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Zuzana HORÁKOVÁ (203 Czech Republic), Eva TOTHOVA (703 Slovakia) and Rom KOSTŘICA (203 Czech Republic, belonging to the institution)

Edition

International Journal of Clinical Oncology, 2010, 1341-9625

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Japan

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

DOI 10.1007/s10147-010-0108-z

Impact factor

Impact factor: 1.437

RIV identification code

RIV/00216224:14110/10:00040779

Organization unit

Faculty of Medicine

UT WoS

000285152500006

Keywords in English

Glutathione peroxidase; Head and neck cancer; Malondialdehyde; oxidative stress; prognostic marker

Abstract

V originále

BACKGROUND: The aim of the study was to investigate the relationships among (a) glutathione peroxidase (GPx) and malondialdehyde (MDA); (b) oncological characteristics (i.e., TNM classification, tumor grade), and; (c) prognosis of head and neck squamous cell carcinoma. METHODS: In a prospective cohort study, we followed 88 patients for 67.4 months (median 40.3) after surgery for head and neck squamous cell carcinoma. Activity of GPx was determined by ELISA and plasma MDA concentration by liquid chromatography. RESULTS: Lower GPx activity was observed in the T3/4 patients than in the T1/2 group. Tumor grade was significantly correlated with both GPx (P = 0.001) and MDA (P = 0.05, both Spearman). The perioperative level of MDA was higher in patients who later recurred during the follow-up period (n = 15) than in the complete remission group (P = 0.01, Mann-Whitney). Median disease-free interval and overall survival in the group with MDA > median were 29.5 and 32.0 months, respectively, and 38.4 and 40.3 months in the patient group with MDA

Links

NR9200, research and development project

Name: Dynamika oxidativního stresu během onkoterapie ve vztahu k prognóze u pacientů s karcinomy hlavy a krku

Investor: Ministry of Health of the CR

Citovat

SALZMAN, Richard, Lukáš PÁCAL, Kateřina KAŇKOVÁ, Josef TOMANDL, Zuzana HORÁKOVÁ, Eva TOTHOVA and Rom KOSTŘICA. High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma. International Journal of Clinical Oncology. 2010, vol. 15, No 6, p. 565-570. ISSN 1341-9625.

@article{891840,
   author = {Salzman, Richard and Pácal, Lukáš and Kaňková, Kateřina and Tomandl, Josef and Horáková, Zuzana and Tothova, Eva and Kostřica, Rom},
   article_number = {6},
   keywords = {Glutathione peroxidase; Head and neck cancer; Malondialdehyde; oxidative stress; prognostic marker},
   language = {eng},
   issn = {1341-9625},
   journal = {International Journal of Clinical Oncology},
   title = {High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma},
   url = {http://www.springerlink.com/content/3826221v40j17251/fulltext.pdf},
   volume = {15},
   year = {2010}
}

TY  - JOUR
ID  - 891840
AU  - Salzman, Richard - Pácal, Lukáš - Kaňková, Kateřina - Tomandl, Josef - Horáková, Zuzana - Tothova, Eva - Kostřica, Rom
PY  - 2010
TI  - High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma
JF  - International Journal of Clinical Oncology
VL  - 15
IS  - 6
SP  - 565-570
EP  - 565-570
SN  - 13419625
KW  - Glutathione peroxidase
KW  - Head and neck cancer
KW  - Malondialdehyde
KW  - oxidative stress
KW  - prognostic marker
UR  - http://www.springerlink.com/content/3826221v40j17251/fulltext.pdf
N2  - BACKGROUND: The aim of the study was to investigate the relationships among (a) glutathione peroxidase (GPx) and malondialdehyde (MDA); (b) oncological characteristics (i.e., TNM classification, tumor grade), and; (c) prognosis of head and neck squamous cell carcinoma. METHODS: In a prospective cohort study, we followed 88 patients for 67.4 months (median 40.3) after surgery for head and neck squamous cell carcinoma. Activity of GPx was determined by ELISA and plasma MDA concentration by liquid chromatography. RESULTS: Lower GPx activity was observed in the T3/4 patients than in the T1/2 group. Tumor grade was significantly correlated with both GPx (P = 0.001) and MDA (P = 0.05, both Spearman). The perioperative level of MDA was higher in patients who later recurred during the follow-up period (n = 15) than in the complete remission group (P = 0.01, Mann-Whitney). Median disease-free interval and overall survival in the group with MDA > median were 29.5 and 32.0 months, respectively, and 38.4 and 40.3 months in the patient group with MDA
ER  -

SALZMAN, Richard, Lukáš PÁCAL, Kateřina KAŇKOVÁ, Josef TOMANDL, Zuzana HORÁKOVÁ, Eva TOTHOVA and Rom KOSTŘICA. High perioperative level of oxidative stress as a prognostic tool for identifying patients with a high risk of recurrence of head and neck squamous cell carcinoma. \textit{International Journal of Clinical Oncology}. 2010, vol.~15, No~6, p.~565-570. ISSN~1341-9625.

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