Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy

SLABÝ, Ondřej, Jana JANČOVIČOVA, Radek LAKOMÝ, Marek SVOBODA, Alexandr POPRACH, Pavel FABIAN, Leoš KŘEN, Jaroslav MICHÁLEK and Rostislav VYZULA. Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy. Journal of experimental & clinical cancer research. England: BioMed Central, 2010, vol. 29, JUL 7 2010, p. "nestrankovano", 7 pp. ISSN 1756-9966. Available from: https://dx.doi.org/10.1186/1756-9966-29-90.

Basic information

• Original name: Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
• Name in Czech: Exprese miRNA-106b u konvenčního renálního karcinomu je možný marker pro predikci časných metastáz po nefrektomii
• Authors: SLABÝ, Ondřej (203 Czech Republic, guarantor, belonging to the institution), Jana JANČOVIČOVA (703 Slovakia, belonging to the institution), Radek LAKOMÝ (203 Czech Republic, belonging to the institution), Marek SVOBODA (203 Czech Republic, belonging to the institution), Alexandr POPRACH (203 Czech Republic, belonging to the institution), Pavel FABIAN (203 Czech Republic), Leoš KŘEN (203 Czech Republic, belonging to the institution), Jaroslav MICHÁLEK (203 Czech Republic, belonging to the institution) and Rostislav VYZULA (203 Czech Republic, belonging to the institution).
• Edition: Journal of experimental & clinical cancer research, England, BioMed Central, 2010, 1756-9966.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.921
• RIV identification code: RIV/00216224:14110/10:00051416
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1186/1756-9966-29-90
• UT WoS: 000280161800001
• Keywords (in Czech): MikroRNA; ranální buněčný karcinom; miRNA-106b; nefrektomie
• Keywords in English: MicroRNA; renal cell carcinoma; miRNA-106b; nephrectomy
• Tags: International impact

Abstract

MicroRNAs are endogenously expressed regulatory noncoding RNAs. We examined the expression levels of selected microRNAs in 38 samples of conventional renal cell carcinoma (RCC) and 10 samples of non-tumoral renal parenchyma using TaqMan real-time PCR method. We have confirmed previous observations obtained by miRNA microarray analysis using standardized real-time PCR method. For the first time, we have identified a prognostic significance of miRNA-106b, which, after validation on a larger group of patients, maybe useful as a promising biomarker in patients with RCC.

Abstract (in Czech)

MikroRNA jsou endogeně exprimované regulační nekódující RNA. V rámci této publikace jsme stanovovali hladiny vybraných miRNA u 38 vzorků konvenčního renálního karcinomu a u 10 vzorků nenádorového parenchymu. Byla použita metoda TaqMan real-time PCR. Identifikovali jsme prognostický význam miRNA-106b, která po následné validaci na větším souboru pacientů může být využita jako biomarker u pacientů s RCC.