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LITZMAN, Jiří, Dagmar ŠTIKAROVSKÁ, Zdenka PIKULOVÁ, Tomáš PAVLÍK, Sáva PEŠÁK, Vojtěch THON, Pavel KUKLÍNEK a Jindřich LOKAJ. Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre. Online. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010, roč. 153, č. 1, s. 95-101. ISSN 1018-2438. Dostupné z: https://dx.doi.org/10.1159/000301584. [citováno 2024-04-23]

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TY  - JOUR
ID  - 892963
AU  - Litzman, Jiří - Štikarovská, Dagmar - Pikulová, Zdenka - Pavlík, Tomáš - Pešák, Sáva - Thon, Vojtěch - Kuklínek, Pavel - Lokaj, Jindřich
PY  - 2010
TI  - Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre
JF  - INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
VL  - 153
IS  - 1
SP  - 95-101
EP  - 95-101
SN  - 10182438
KW  - Common variable immunodeficiency
KW  - X-linked agammaglobulinaemia
KW  - Immunoglobulins
N2  - Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Also, the median number of pneumonia episodes during the diagnostic delay decreased from 5 in the 1980s, to 1 in the 1990s and to 0 in the period of 2001-2008 (Spearmans correlation coefficient). While in the 1980s 17 of the 19 patients had pneumonia in their past history, in the period of 2001-2008 only 13 of the 33 patients were concerned. Conclusions: Our observation documents improved awareness of immunodeficiencies among physicians. It is supposed that earlier diagnosis will prevent complications, improve the quality of life and even survival of hypogammaglobulinaemic patients.
ER  -

Základní údaje
Originální název	Change in Referral Diagnoses and Diagnostic Delay in Hypogammaglobulinaemic Patients during 28 Years in a Single Referral Centre
Autoři	LITZMAN, Jiří (203 Česká republika, garant, domácí), Dagmar ŠTIKAROVSKÁ (203 Česká republika), Zdenka PIKULOVÁ (203 Česká republika), Tomáš PAVLÍK (203 Česká republika, domácí), Sáva PEŠÁK (203 Česká republika, domácí), Vojtěch THON (203 Česká republika, domácí), Pavel KUKLÍNEK (203 Česká republika, domácí) a Jindřich LOKAJ (203 Česká republika, domácí)
Vydání	INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2010, 1018-2438.

Další údaje
Originální jazyk	angličtina
Typ výsledku	Článek v odborném periodiku
Obor	30102 Immunology
Stát vydavatele	Švýcarsko
Utajení	není předmětem státního či obchodního tajemství
Impakt faktor	Impact factor: 2.235
Kód RIV	RIV/00216224:14110/10:00051417
Organizační jednotka	Lékařská fakulta
Doi	http://dx.doi.org/10.1159/000301584
UT WoS	000279595800012
Klíčová slova anglicky	Common variable immunodeficiency; X-linked agammaglobulinaemia; Immunoglobulins
Příznaky	Mezinárodní význam
Změnil	Změnil: Mgr. Michal Petr, učo 65024. Změněno: 20. 4. 2012 11:15.

Anotace
Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Also, the median number of pneumonia episodes during the diagnostic delay decreased from 5 in the 1980s, to 1 in the 1990s and to 0 in the period of 2001-2008 (Spearmans correlation coefficient). While in the 1980s 17 of the 19 patients had pneumonia in their past history, in the period of 2001-2008 only 13 of the 33 patients were concerned. Conclusions: Our observation documents improved awareness of immunodeficiencies among physicians. It is supposed that earlier diagnosis will prevent complications, improve the quality of life and even survival of hypogammaglobulinaemic patients.

Anotace

Background: The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of serum immunoglobulin laboratory determination was not sufficient, leading to a significant diagnostic delay. Methods: We have analysed the diagnostic delay and referral diagnoses in patients in whom any form of primary hypogammaglobulinaemia had been diagnosed at our department, which was established in 1981. Results: Comparing the diagnostic delay in the 1980s (19 patients, median 5.5 years), the 1990s (37 patients, median 3.5 years) and the years 2001-2008 (33 patients, median 1 year), a significant decrease was observed (Spearmans correlation coefficient). Also, the median number of pneumonia episodes during the diagnostic delay decreased from 5 in the 1980s, to 1 in the 1990s and to 0 in the period of 2001-2008 (Spearmans correlation coefficient). While in the 1980s 17 of the 19 patients had pneumonia in their past history, in the period of 2001-2008 only 13 of the 33 patients were concerned. Conclusions: Our observation documents improved awareness of immunodeficiencies among physicians. It is supposed that earlier diagnosis will prevent complications, improve the quality of life and even survival of hypogammaglobulinaemic patients.