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@proceedings{893719,
author = {Gumulec, Jaromír and Masařík, Michal and Kuchtíčková, Šárka and Kudláčková, Veronika and Jurajda, Michal and Pavlík, Dušan and Rovný, Arne and Hrabec, Roman and Křížková, Soňa and Kizek, René},
booktitle = {XIV. Setkání biochemiků a molekulárních biologů},
keywords = {metalothionein;prostate cancer;tumor marker;zinc;},
language = {eng},
isbn = {978-80-210-5164-5},
title = {Determination of Metallothionein in prostate tumor cell lines},
url = {http://orion.chemi.muni.cz/setkani/Setkani14/index.htm},
year = {2010}
}
TY - CONF
ID - 893719
AU - Gumulec, Jaromír - Masařík, Michal - Kuchtíčková, Šárka - Kudláčková, Veronika - Jurajda, Michal - Pavlík, Dušan - Rovný, Arne - Hrabec, Roman - Křížková, Soňa - Kizek, René
PY - 2010
TI - Determination of Metallothionein in prostate tumor cell lines
SN - 9788021051645
KW - metalothionein;prostate cancer;tumor marker;zinc;
UR - http://orion.chemi.muni.cz/setkani/Setkani14/index.htm
N2 - Prostate carcinoma (PCa) is the most common tumor and second leading cause of death due to cancer of men. Proteins such as metallothionein (MT) or alpha-methyl-CoA-racemase (AMACR) are highly overexpressed in prostate carcinoma. Althrough the role of these proteins in tumour tissue remains still unclear, it fulfills the requirements of higher specificity, which AMACR achieves at almost 100%. We have analyzed both proteins from prostate cancer cell lines LNCaP, PC-3 and 22RVL, compared to healthy prostate cell line PNT1A and then from PCa patients' serum compared to healthy serum controls. We've used immunohistochemical analysis, immunoprecipitation with magnetic nanoparticles, PAGE and dot blots. In all of these methods, we've found significant increase of expression in these samples.
ER -
GUMULEC, Jaromír, Michal MASAŘÍK, Šárka KUCHTÍČKOVÁ, Veronika KUDLÁČKOVÁ, Michal JURAJDA, Dušan PAVLÍK, Arne ROVNÝ, Roman HRABEC, Soňa KŘÍŽKOVÁ a René KIZEK. Determination of Metallothionein in prostate tumor cell lines. Online. In \textit{XIV. Setkání biochemiků a molekulárních biologů}. 2010. ISBN~978-80-210-5164-5. [citováno 2024-04-24]
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