PÁCAL, Lukáš, Josef TOMANDL, Jan SVOJANOVSKÝ, Darja KRUSOVÁ, Soňa ŠTĚPÁNKOVÁ, Jitka ŘEHOŘOVÁ, Jindřich OLŠOVSKÝ, Jana BĚLOBRÁDKOVÁ, Veronika TANHÄUSEROVÁ, Marie TOMANDLOVÁ, Jan MUŽÍK and Kateřina KAŇKOVÁ. Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy. Nephrology Dialysis Transplantation. Velká Británie: Oxford University Press, 2010, vol. 26, No 4, p. 1229-1236, 4 pp. ISSN 0931-0509. |
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@article{894948, author = {Pácal, Lukáš and Tomandl, Josef and Svojanovský, Jan and Krusová, Darja and Štěpánková, Soňa and Řehořová, Jitka and Olšovský, Jindřich and Bělobrádková, Jana and Tanhäuserová, Veronika and Tomandlová, Marie and Mužík, Jan and Kaňková, Kateřina}, article_location = {Velká Británie}, article_number = {4}, keywords = {diabetic nephropathy; pentose phosphate pathway; thiamine; thiamine deficiency; transaldolase; transketolase}, language = {eng}, issn = {0931-0509}, journal = {Nephrology Dialysis Transplantation}, title = {Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy}, volume = {26}, year = {2010} }
TY - JOUR ID - 894948 AU - Pácal, Lukáš - Tomandl, Josef - Svojanovský, Jan - Krusová, Darja - Štěpánková, Soňa - Řehořová, Jitka - Olšovský, Jindřich - Bělobrádková, Jana - Tanhäuserová, Veronika - Tomandlová, Marie - Mužík, Jan - Kaňková, Kateřina PY - 2010 TI - Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy JF - Nephrology Dialysis Transplantation VL - 26 IS - 4 SP - 1229-1236 EP - 1229-1236 PB - Oxford University Press SN - 09310509 KW - diabetic nephropathy KW - pentose phosphate pathway KW - thiamine KW - thiamine deficiency KW - transaldolase KW - transketolase N2 - Results of this study indicate dysfunction/deficit of intracellular active form of thiamine in diabetics which serves as a cofactor for transketolase - the key enzyme of pentose phosphate pathway which is considered one of the few potentially counterbalancing pathways opposing hyperglycemia effects. Ascertained functional thiamine deficiency in diabetes, especially when accompanied with advanced renal disease, could be potentially a critical abnormality influencing the activity of pentose phosphate pathway, development if hyperglycemia-mediated damage and diabetic complications and also target of event. pharmacologic interventions. ER -
PÁCAL, Lukáš, Josef TOMANDL, Jan SVOJANOVSKÝ, Darja KRUSOVÁ, Soňa ŠTĚPÁNKOVÁ, Jitka ŘEHOŘOVÁ, Jindřich OLŠOVSKÝ, Jana BĚLOBRÁDKOVÁ, Veronika TANHÄUSEROVÁ, Marie TOMANDLOVÁ, Jan MUŽÍK and Kateřina KAŇKOVÁ. Role of thiamine status and genetic variability in transketolase and other pentose phosphate cycle enzymes in the progression of diabetic nephropathy. \textit{Nephrology Dialysis Transplantation}. Velká Británie: Oxford University Press, 2010, vol.~26, No~4, p.~1229-1236, 4 pp. ISSN~0931-0509.
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