| PÁCAL, Lukáš, Veronika TANHÄUSEROVÁ, Jan SVOJANOVSKÝ, Darja KRUSOVÁ, Soňa ŠTĚPÁNKOVÁ, Jindřich OLŠOVSKÝ, Jana BĚLOBRÁDKOVÁ, Jitka ŘEHOŘOVÁ, Jana SMRŽOVÁ and Kateřina KAŇKOVÁ. Does genetic variability in the fructosamine-3-kinase play a role in the progression of diabetic nephropathy, morbidity and mortality of diabetics? In Diabetologia. 2010. ISSN 0012-186X. |
Other formats:
BibTeX
LaTeX
RIS
@proceedings{895659,
author = {Pácal, Lukáš and Tanhäuserová, Veronika and Svojanovský, Jan and Krusová, Darja and Štěpánková, Soňa and Olšovský, Jindřich and Bělobrádková, Jana and Řehořová, Jitka and Smržová, Jana and Kaňková, Kateřina},
booktitle = {Diabetologia},
keywords = {fructosamine-3-kinase; polymorphism; diabetic nephropathy; mortality},
language = {eng},
title = {Does genetic variability in the fructosamine-3-kinase play a role in the progression of diabetic nephropathy, morbidity and mortality of diabetics?},
year = {2010}
}
TY - CONF
ID - 895659
AU - Pácal, Lukáš - Tanhäuserová, Veronika - Svojanovský, Jan - Krusová, Darja - Štěpánková, Soňa - Olšovský, Jindřich - Bělobrádková, Jana - Řehořová, Jitka - Smržová, Jana - Kaňková, Kateřina
PY - 2010
TI - Does genetic variability in the fructosamine-3-kinase play a role in the progression of diabetic nephropathy, morbidity and mortality of diabetics?
KW - fructosamine-3-kinase
KW - polymorphism
KW - diabetic nephropathy
KW - mortality
N2 - Fructosamines are products of non-enzymatic glycation formed in accelerated rate during hyperglycemia. As precursors of advanced glycation end-products (AGEs) fructosamines supposedly contribute to the development of glucotoxic injury. Mechanism of enzymatic deglycation of proteins in vivo by fructosamine-3-kinase (FN3K) was described recently. The -385A/G (rs3859206) and 900C/G (rs1056534) single nucleotide polymorphisms (SNPs) in the FN3K gene were found to have potential functional impact.The aim was to study relationship between polymorphisms in FN3K gene, progression of diabetic nephropathy (DN) and cardiovascular morbidity and mortality of diabetics. Based on our results, we can not identify high FN3K deglycating activity as a protective factor, on the contrary higher rate of 3-deoxyglucosone formation may counterbalance putative protection by providing substrate for Arg-directed glycation and AGE formation.
ER -
PÁCAL, Lukáš, Veronika TANHÄUSEROVÁ, Jan SVOJANOVSKÝ, Darja KRUSOVÁ, Soňa ŠTĚPÁNKOVÁ, Jindřich OLŠOVSKÝ, Jana BĚLOBRÁDKOVÁ, Jitka ŘEHOŘOVÁ, Jana SMRŽOVÁ and Kateřina KAŇKOVÁ. Does genetic variability in the fructosamine-3-kinase play a role in the progression of diabetic nephropathy, morbidity and mortality of diabetics? In \textit{Diabetologia}. 2010. ISSN~0012-186X.
|
