| PALEČEK, Jan, Kateřina BEDNÁŘOVÁ, Jessica HUDSON, Lucie KOZÁKOVÁ, Marc GUÉRINEAU, Chunyan LIAO, Rita COLNAGHI, Jaromír MAREK, Susanne VIDOT a Alan LEHMANN. The Nse3/MAGE and Nse4/EID proteins are involved in transcription regulation. Online. In 75th Cold Spring Harbor Symposium on Qunatitative Biology: Nuclear organization and function. 2010, [citováno 2024-04-24] |
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@proceedings{895852,
author = {Paleček, Jan and Bednářová, Kateřina and Hudson, Jessica and Kozáková, Lucie and Guérineau, Marc and Liao, Chunyan and Colnaghi, Rita and Marek, Jaromír and Vidot, Susanne and Lehmann, Alan},
booktitle = {75th Cold Spring Harbor Symposium on Qunatitative Biology: Nuclear organization and function},
keywords = {SMC5-6 complex; Nse3/MAGE proteins; Nse4/EID proteins; transcription regulation},
language = {eng},
title = {The Nse3/MAGE and Nse4/EID proteins are involved in transcription regulation},
year = {2010}
}
TY - CONF
ID - 895852
AU - Paleček, Jan - Bednářová, Kateřina - Hudson, Jessica - Kozáková, Lucie - Guérineau, Marc - Liao, Chunyan - Colnaghi, Rita - Marek, Jaromír - Vidot, Susanne - Lehmann, Alan
PY - 2010
TI - The Nse3/MAGE and Nse4/EID proteins are involved in transcription regulation
KW - SMC5-6 complex
KW - Nse3/MAGE proteins
KW - Nse4/EID proteins
KW - transcription regulation
N2 - The SMC5/6 complex is composed of two subcomplexes SMC5-SMC6-Nse2 and Nse1-Nse3-Nse4. Nse3 shows sequence similarity to the MAGE (Melanoma Antigen Gene) family of proteins, which are overexpressed in certain types of cancers and whose function has been linked to cell cycle regulation, apoptosis and neuronal development. Using site-directed mutagenesis, protein-protein interaction analyses and modelling of the Schizosaccharomyces pombe Nse3 onto the crystal structure of the MAGEA4 protein, we have identified surfaces on the C- and N-terminal domains of Nse3 that interact respectively with Nse4 and Nse1. The binding site for Nse4 is evolutionarily conserved within the Nse3/MAGE superfamily of proteins. Nse4 is related to the EID (E1A-like inhibitor of differentiation) family of transcriptional repressors. We show that there is interaction between members of the MAGE family and those of the EID family. Our data suggest that the Nse3/MAGE and Nse4/EID proteins are involved in gene regulation.
ER -
PALEČEK, Jan, Kateřina BEDNÁŘOVÁ, Jessica HUDSON, Lucie KOZÁKOVÁ, Marc GUÉRINEAU, Chunyan LIAO, Rita COLNAGHI, Jaromír MAREK, Susanne VIDOT a Alan LEHMANN. The Nse3/MAGE and Nse4/EID proteins are involved in transcription regulation. Online. In \textit{75th Cold Spring Harbor Symposium on Qunatitative Biology: Nuclear organization and function}. 2010, [citováno 2024-04-24]
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