VESELÁ, Iva, Hana KOTASOVÁ, Štěpánka JANKOVSKÁ, Jiřina PROCHÁZKOVÁ and Jiří PACHERNÍK. Leukaemia Inhibitory Factor Inhibits Cardiomyogenesis of Mouse Embryonic Stem Cells via STAT3 Activation. Folia biologica. Praha, 2010, neuveden, No 56, p. 165-72, 8 pp. ISSN 0015-5500.
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Basic information
Original name Leukaemia Inhibitory Factor Inhibits Cardiomyogenesis of Mouse Embryonic Stem Cells via STAT3 Activation
Authors VESELÁ, Iva (203 Czech Republic, belonging to the institution), Hana KOTASOVÁ (203 Czech Republic, belonging to the institution), Štěpánka JANKOVSKÁ (203 Czech Republic), Jiřina PROCHÁZKOVÁ (203 Czech Republic, belonging to the institution) and Jiří PACHERNÍK (203 Czech Republic, guarantor, belonging to the institution).
Edition Folia biologica, Praha, 2010, 0015-5500.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.729
RIV identification code RIV/00216224:14310/10:00044713
Organization unit Faculty of Science
UT WoS 000281924500004
Keywords in English LIF; Cardiomyocytes; embryonic stem cells; STAT3
Tags International impact, Reviewed
Changed by Changed by: Ing. Zdeňka Rašková, učo 140529. Changed: 1/8/2013 13:43.
Abstract
LIF is a cytokine that exhibits pleiotropic activities in a wide range of cell types. there are evidences that LIF-regulated signaling pathway are involved in cardiomyogenesis. We studied the effect of LIF on cardiomyogenesis in presence of serum-born factors. We found out that LIF had an inhibitory effect during the induction and progression phases of cardiomyogenesis of mES cells. This effect was abolished by inhibitors of STAT3 activity.
Links
GA301/08/0717, research and development projectName: Regulace diferenciace ES buněk prostřednictvím receptoru gp130
Investor: Czech Science Foundation, Gp130 receptor-mediated differentiation of ES cells
GD204/09/H058, research and development projectName: Mezibuněčná signalizace ve vývoji organismu a vzniku onemocnění
Investor: Czech Science Foundation, Intercellular signalling in development and disease
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