Interferon-gamma +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria

IZAKOVIČOVÁ HOLLÁ, Lydie, Barbara HRDLIČKOVÁ, Petra LINHARTOVÁ and Antonín FASSMANN. Interferon-gamma +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria. Archives of Oral Biology. Amsterodam: Elsevier, 2011, vol. 56, No 2, p. 153-158. ISSN 0003-9969. Available from: https://dx.doi.org/10.1016/j.archoralbio.2010.09.005.

Basic information

• Original name: Interferon-gamma +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria
• Name in Czech: Vztah interferon-gamma +874A/T polymorfizmu ke generalizované chronické parodontitidě a přítomnosti parodontálních patogenů
• Authors: IZAKOVIČOVÁ HOLLÁ, Lydie (203 Czech Republic, guarantor, belonging to the institution), Barbara HRDLIČKOVÁ (203 Czech Republic, belonging to the institution), Petra LINHARTOVÁ (203 Czech Republic, belonging to the institution) and Antonín FASSMANN (203 Czech Republic, belonging to the institution).
• Edition: Archives of Oral Biology, Amsterodam, Elsevier, 2011, 0003-9969.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.603
• RIV identification code: RIV/00216224:14110/11:00051442
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.archoralbio.2010.09.005
• UT WoS: 000287465500007
• Keywords (in Czech): genový polymorfizmus; interferon-gamma; mikroorganizmus; parodontitida
• Keywords in English: gene polymorphism; interferon-gamma; microorganism; periodontitis
• Tags: International impact

Abstract

Interferon gamma (IFN-gamma) is one of the key regulatory cytokines that has a significant effect on immune responses. It may be important in the chronic inflammatory diseases such as periodontitis in which increased IFN-gamma levels were found. The aim of this study was to analyze +874A/T polymorphism in the IFN-gamma gene and its associations with the presence of periodontopathic bacteria and susceptibility to generalized chronic periodontitis (CP). Our results showed no differences in the allele and genotype frequencies of the IFN-gamma +874A/T polymorphism between patients with CP and controls (p<0.05). Although we found significant differences in the occurrence of periodontal bacteria between patients with CP and healthy controls (from p<0.00001 to p<0.05), no significant association between IFN-gamma +874A/T polymorphism and periodontal pathogens was observed in any group.

Abstract (in Czech)

Interferon-gamma (IFN-gamma) je jedním z klíčových regulačních cytokinů, které hrají roli v imunitní odpovědi. Je důležitým faktorem u chronických zánětlivých nemocí jako je parodontitida, u níž byly nalezeny zvýšené hladiny IFN-gamma. Cílem naší práce bylo analyzovat frekvence IFN-gamma +874A/T varianty a jeho možnou asociaci s výskytem parodontálních patogenů, příp. náchylností k rozvoji generalizované chronické parodontitidy (CP). Naše výsledky neprokázaly významné rozdíly ve frekvencích IFN-gamma+874A/T polymorfizmu mezi pacienty s CP a kontrolami. Ačkoliv jsme našli významné rozdíly ve výskytu parodontálních patogenů mezi pacienty s CP a kontrolními osobami (from p<0.00001 to p<0.05), vztah mezi IFN-gamma +874A/T variantou a přítomností parodontálních patogenů nebyl signifikantní.

Links

• NT11405, research and development project: Name: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu

Investor: Ministry of Health of the CR

• 1M0528, research and development project: Name: Stomatologické výzkumné centrum

Investor: Ministry of Education, Youth and Sports of the CR, Dental research centre