No association of FCRN promoter VNTR polymorphism with the rate
of maternal-fetal IgG transfer

J 2010

No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer

FREIBERGER, Tomáš, Barbora RAVČUKOVÁ, Lucie GRODECKÁ, Barbora KUŘECOVÁ, Jiří JARKOVSKÝ et. al.

Basic information

Original name

No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer

Authors

FREIBERGER, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Barbora RAVČUKOVÁ (203 Czech Republic), Lucie GRODECKÁ (203 Czech Republic), Barbora KUŘECOVÁ (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Dana BARTOŇKOVÁ (203 Czech Republic, belonging to the institution), Vojtěch THON (203 Czech Republic, belonging to the institution) and Jiří LITZMAN (203 Czech Republic, belonging to the institution)

Edition

Journal of Reproductive Immunology, Elsevier, 2010, 0165-0378

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.204

RIV identification code

RIV/00216224:14110/10:00051452

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jri.2010.04.002

UT WoS

000279888600010

Keywords (in Czech)

Neonatální Fc receptor; FcRn; VNTR; Maternofetální transfer IgG

Keywords in English

Neonatal Fc receptor; FcRn; VNTR; Polymorphism; Maternal-fetal IgG transfer

Abstract

V originále

The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio.

Citovat

FREIBERGER, Tomáš, Barbora RAVČUKOVÁ, Lucie GRODECKÁ, Barbora KUŘECOVÁ, Jiří JARKOVSKÝ, Dana BARTOŇKOVÁ, Vojtěch THON and Jiří LITZMAN. No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer. Journal of Reproductive Immunology. Elsevier, 2010, vol. 85, No 2, p. 193-197. ISSN 0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2010.04.002.

@article{897916,
   author = {Freiberger, Tomáš and Ravčuková, Barbora and Grodecká, Lucie and Kuřecová, Barbora and Jarkovský, Jiří and Bartoňková, Dana and Thon, Vojtěch and Litzman, Jiří},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jri.2010.04.002},
   keywords = {Neonatal Fc receptor; FcRn; VNTR; Polymorphism; Maternal-fetal IgG transfer},
   language = {eng},
   issn = {0165-0378},
   journal = {Journal of Reproductive Immunology},
   title = {No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer},
   volume = {85},
   year = {2010}
}

TY  - JOUR
ID  - 897916
AU  - Freiberger, Tomáš - Ravčuková, Barbora - Grodecká, Lucie - Kuřecová, Barbora - Jarkovský, Jiří - Bartoňková, Dana - Thon, Vojtěch - Litzman, Jiří
PY  - 2010
TI  - No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer
JF  - Journal of Reproductive Immunology
VL  - 85
IS  - 2
SP  - 193-197
EP  - 193-197
PB  - Elsevier
SN  - 01650378
KW  - Neonatal Fc receptor
KW  - FcRn
KW  - VNTR
KW  - Polymorphism
KW  - Maternal-fetal IgG transfer
N2  - The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio.
ER  -

FREIBERGER, Tomáš, Barbora RAVČUKOVÁ, Lucie GRODECKÁ, Barbora KUŘECOVÁ, Jiří JARKOVSKÝ, Dana BARTOŇKOVÁ, Vojtěch THON and Jiří LITZMAN. No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer. \textit{Journal of Reproductive Immunology}. Elsevier, 2010, vol.~85, No~2, p.~193-197. ISSN~0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2010.04.002.

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