FREIBERGER, Tomáš, Barbora RAVČUKOVÁ, Lucie GRODECKÁ, Barbora KUŘECOVÁ, Jiří JARKOVSKÝ, Dana BARTOŇKOVÁ, Vojtěch THON and Jiří LITZMAN. No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer. Journal of Reproductive Immunology. Elsevier, 2010, vol. 85, No 2, p. 193-197. ISSN 0165-0378. Available from: https://dx.doi.org/10.1016/j.jri.2010.04.002.
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Basic information
Original name No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer
Authors FREIBERGER, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Barbora RAVČUKOVÁ (203 Czech Republic), Lucie GRODECKÁ (203 Czech Republic), Barbora KUŘECOVÁ (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Dana BARTOŇKOVÁ (203 Czech Republic, belonging to the institution), Vojtěch THON (203 Czech Republic, belonging to the institution) and Jiří LITZMAN (203 Czech Republic, belonging to the institution).
Edition Journal of Reproductive Immunology, Elsevier, 2010, 0165-0378.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.204
RIV identification code RIV/00216224:14110/10:00051452
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jri.2010.04.002
UT WoS 000279888600010
Keywords (in Czech) Neonatální Fc receptor; FcRn; VNTR; Maternofetální transfer IgG
Keywords in English Neonatal Fc receptor; FcRn; VNTR; Polymorphism; Maternal-fetal IgG transfer
Tags International impact
Changed by Changed by: Mgr. Michal Petr, učo 65024. Changed: 10/4/2012 08:59.
Abstract
The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio.
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