Proteomic Analysis in Multiple Myeloma Research

ČUMOVÁ, Jana, Anna POTÁČOVÁ, Zbyněk ZDRÁHAL and Roman HÁJEK. Proteomic Analysis in Multiple Myeloma Research. Molecular biotechnology. USA: Humana Press, 2011, vol. 47, No 1, p. 83-93. ISSN 1073-6085. Available from: https://dx.doi.org/10.1007/s12033-010-9326-x.

Basic information

• Original name: Proteomic Analysis in Multiple Myeloma Research
• Name in Czech: Proteomická analýza ve výzkumu mnohočetného myelomu
• Authors: ČUMOVÁ, Jana (203 Czech Republic, belonging to the institution), Anna POTÁČOVÁ (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution) and Roman HÁJEK (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Molecular biotechnology, USA, Humana Press, 2011, 1073-6085.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.171
• RIV identification code: RIV/00216224:14110/11:00051461
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s12033-010-9326-x
• UT WoS: 000285472500010
• Keywords (in Czech): proteomika; mnohočetný myelom; hmotnostní spektrometrie; biomarker
• Keywords in English: proteomics; multiple myeloma; mass spectrometry; biomarker
• Tags: International impact

Abstract

Multiple myeloma (MM) is an incurable plasma cell (PC) malignancy characterized by the accumulation of monoclonal PCs in the bone marrow. For deeper understanding of the molecular mechanisms involved in the development of this disease, the influence of microenvironment, or the prediction of response of tumor PCs to anti-MM treatment, it is possible to use modern technologies for genomic and proteomic analyses. Due to progress in instrumentation, one of the main tools of proteomic analysis is mass spectrometry in combination with chosen separation techniques. This review will provide a short survey of the most commonly used proteomic techniques and show examples of their applications in MM proteome studies.

Abstract (in Czech)

V této souhrnné práci popisujeme nejnovější poznatky a metodiky v proteomickém výzkumu mnohočetného myelomu.

Links

• LC06027, research and development project: Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)

Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group

• MSM0021622415, plan (intention): Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations

• MSM0021622434, plan (intention): Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií

Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies