J 2011

Proteomic Analysis in Multiple Myeloma Research

ČUMOVÁ, Jana, Anna POTÁČOVÁ, Zbyněk ZDRÁHAL and Roman HÁJEK

Basic information

Original name

Proteomic Analysis in Multiple Myeloma Research

Name in Czech

Proteomická analýza ve výzkumu mnohočetného myelomu

Authors

ČUMOVÁ, Jana (203 Czech Republic, belonging to the institution), Anna POTÁČOVÁ (203 Czech Republic, belonging to the institution), Zbyněk ZDRÁHAL (203 Czech Republic, belonging to the institution) and Roman HÁJEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Molecular biotechnology, USA, Humana Press, 2011, 1073-6085

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.171

RIV identification code

RIV/00216224:14110/11:00051461

Organization unit

Faculty of Medicine

DOI

UT WoS

000285472500010

Keywords (in Czech)

proteomika; mnohočetný myelom; hmotnostní spektrometrie; biomarker

Keywords in English

proteomics; multiple myeloma; mass spectrometry; biomarker

Tags

International impact
Změněno: 12/4/2012 09:13, Mgr. Michal Petr

Abstract

ORIG CZ

V originále

Multiple myeloma (MM) is an incurable plasma cell (PC) malignancy characterized by the accumulation of monoclonal PCs in the bone marrow. For deeper understanding of the molecular mechanisms involved in the development of this disease, the influence of microenvironment, or the prediction of response of tumor PCs to anti-MM treatment, it is possible to use modern technologies for genomic and proteomic analyses. Due to progress in instrumentation, one of the main tools of proteomic analysis is mass spectrometry in combination with chosen separation techniques. This review will provide a short survey of the most commonly used proteomic techniques and show examples of their applications in MM proteome studies.

In Czech

V této souhrnné práci popisujeme nejnovější poznatky a metodiky v proteomickém výzkumu mnohočetného myelomu.

Links

LC06027, research and development project
Name: Univerzitní výzkumné centrum - Česká myelomová skupina (Acronym: LC MGUS)
Investor: Ministry of Education, Youth and Sports of the CR, University Research Centre - Czech Myeloma Group
MSM0021622415, plan (intention)
Name: Molekulární podstata buněčných a tkáňových regulací
Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations
MSM0021622434, plan (intention)
Name: Od klasických prognostických markerů ke klinicky aplikovatelným farmakogenomickým a farmakoproteomickým projektům u mnohočetného myelomu a monoklonálních gamapatií
Investor: Ministry of Education, Youth and Sports of the CR, From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies