NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ and Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2010, vol. 1173, Sept, 8 pp. ISSN 0077-8923.
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Basic information
Original name Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.
Authors NĚMEC, Petr (203 Czech Republic, guarantor, belonging to the institution), MP GOLDBERGOVA (203 Czech Republic, belonging to the institution), Jiřina GATTEROVA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Miroslav SOUČEK (203 Czech Republic, belonging to the institution).
Edition Ann N Y Acad Sci, New York, USA, New York Academy of Sciences, 2010, 0077-8923.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.847
RIV identification code RIV/00216224:14110/10:00040797
Organization unit Faculty of Medicine
UT WoS 000270762800070
Keywords in English gene; RA; promoter; IL10; polymorphism
Changed by Changed by: prof. MUDr. Miroslav Souček, CSc., učo 502. Changed: 19/1/2011 15:21.
Abstract
Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
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NR7812, research and development projectName: Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artritidy
Investor: Ministry of Health of the CR
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