Association of polymorphisms in interleukin-10 gene promoter
with autoantibody production in patients with rheumatoid
arthritis.

J 2010

Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ, Miroslav SOUČEK et. al.

Basic information

Original name

Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.

Authors

NĚMEC, Petr (203 Czech Republic, guarantor, belonging to the institution), MP GOLDBERGOVA (203 Czech Republic, belonging to the institution), Jiřina GATTEROVA (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic, belonging to the institution) and Miroslav SOUČEK (203 Czech Republic, belonging to the institution)

Edition

Ann N Y Acad Sci, New York, USA, New York Academy of Sciences, 2010, 0077-8923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.847

RIV identification code

RIV/00216224:14110/10:00040797

Organization unit

Faculty of Medicine

UT WoS

000270762800070

Keywords in English

gene; RA; promoter; IL10; polymorphism

Změněno: 19/1/2011 15:21, prof. MUDr. Miroslav Souček, CSc.

Abstract

V originále

Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.

Links

NR7812, research and development project

Name: Genetická variabilita pro- a proti-zánětlivých cytokinů v patogenezi revmatoidní artritidy

Investor: Ministry of Health of the CR

Citovat

NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ and Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. Ann N Y Acad Sci. New York, USA: New York Academy of Sciences, 2010, vol. 1173, Sept, 8 pp. ISSN 0077-8923.

@article{900500,
   author = {Němec, Petr and Goldbergova, MP and Gatterova, Jiřina and Vašků, Anna and Souček, Miroslav},
   article_location = {New York, USA},
   article_number = {Sept},
   keywords = {gene; RA; promoter; IL10; polymorphism},
   language = {eng},
   issn = {0077-8923},
   journal = {Ann N Y Acad Sci},
   title = {Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.},
   volume = {1173},
   year = {2010}
}

TY  - JOUR
ID  - 900500
AU  - Němec, Petr - Goldbergova, MP - Gatterova, Jiřina - Vašků, Anna - Souček, Miroslav
PY  - 2010
TI  - Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis.
JF  - Ann N Y Acad Sci
VL  - 1173
IS  - Sept
PB  - New York Academy of Sciences
SN  - 00778923
KW  - gene
KW  - RA
KW  - promoter
KW  - IL10
KW  - polymorphism
N2  - Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that plays a crucial role in the regulation of the immune system. Allelic polymorphisms in the IL-10 gene promoter may contribute to the regulation of autoantibody production. To examine the association between both individuals IL-10 single nucleotide polymorphisms and the production of autoantibodies and the radiographic progression of rheumatoid arthritis (RA), a total of 144 RA patients were recruited into the study. We found significant differences in genotype distribution of the -1082G/A polymorphism between IgG, IgA, and IgM rheumatoid factor(RF)-positive/negative RA patients. We also found significant differences in allelic frequencies of the -3575T/A, -819C/T, and -592A/C polymorphisms between anticyclic citrullinated peptide (anti-CCP)-positive/negative RA patients. The haplotype TGAATA was found to be less frequent within anti-CCP-positive RA patients. Results obtained in this study provide evidence of an association between polymorphisms in IL-10 gene promoter and the production of autoantibodies in RA patients.
ER  -

NĚMEC, Petr, MP GOLDBERGOVA, Jiřina GATTEROVA, Anna VAŠKŮ and Miroslav SOUČEK. Association of polymorphisms in interleukin-10 gene promoter with autoantibody production in patients with rheumatoid arthritis. \textit{Ann N Y Acad Sci}. New York, USA: New York Academy of Sciences, 2010, vol.~1173, Sept, 8 pp. ISSN~0077-8923.

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