b-arrestins: scaffolds and signalling elements essential for
WNT/Frizzled signalling pathways?

J 2010

b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

SCHULTE, Gunnar, Alexandra SCHAMBONY and Vitezslav BRYJA

Basic information

Original name

b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

Authors

SCHULTE, Gunnar (752 Sweden), Alexandra SCHAMBONY (276 Germany) and Vitezslav BRYJA (203 Czech Republic, guarantor, belonging to the institution)

Edition

British Journal of Pharmacology, 2010, 1476-5381

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.925

RIV identification code

RIV/00216224:14310/10:00040591

Organization unit

Faculty of Science

UT WoS

000275402000007

Keywords in English

Dishevelled; RYK; ROR; b-catenin; canonical signalling; non-canonical signalling; endocytosis; desensitization; internalization; casein kinase

Změněno: 7/3/2011 11:03, prof. Mgr. Vítězslav Bryja, Ph.D.

Abstract

V originále

Arrestins were originally identified as negative regulators of G protein-coupled receptor signaling. Recently, their diverse functions in intracellular signaling pathways as scaffold and signaling intermediate emerged providing mechanisms for achieving signal specificity and to attack for pharmacological intervention. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signaling. WNTs are secreted lipoglycoproteins acting through the seven transmembrane spanning receptors of the FZD family. During the last years it became evident that beta-arrestins are required for cellular communication by means of WNTs and FZDs both in cellular systems as well as in vivo. Although the overall importance of arrestin for WNT/FZD signaling remains still obscure, interaction with the central phosphoprotein disheveled and the endocytic machinery implicate beta-arrestin as a determinator of WNT signaling specificity, mediator of WNT/FZD desensitization and regulator of signaling compartmentation.

Links

GA204/09/0498, research and development project

Name: Dynamika proteinů interagujících s Dishevelled a jejich význam pro Wnt signálování

Investor: Czech Science Foundation, Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling

KJB501630801, research and development project

Name: Posttranslační modifikace proteinu Dishevelled

Investor: Academy of Sciences of the Czech Republic, Posttranslational modification of Dishevelled

MSM0021622430, plan (intention)

Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies

Citovat

SCHULTE, Gunnar, Alexandra SCHAMBONY and Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?). British Journal of Pharmacology. 2010, vol. 159, No 5, p. 1051-8, 8 pp. ISSN 1476-5381.

@article{900948,
   author = {Schulte, Gunnar and Schambony, Alexandra and Bryja, Vitezslav},
   article_number = {5},
   keywords = {Dishevelled; RYK; ROR; b-catenin; canonical signalling; non-canonical signalling; endocytosis; desensitization; internalization; casein kinase},
   language = {eng},
   issn = {1476-5381},
   journal = {British Journal of Pharmacology},
   title = {b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?},
   volume = {159},
   year = {2010}
}

TY  - JOUR
ID  - 900948
AU  - Schulte, Gunnar - Schambony, Alexandra - Bryja, Vitezslav
PY  - 2010
TI  - b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?
JF  - British Journal of Pharmacology
VL  - 159
IS  - 5
SP  - 1051-8
EP  - 1051-8
SN  - 14765381
KW  - Dishevelled
KW  - RYK
KW  - ROR
KW  - b-catenin
KW  - canonical signalling
KW  - non-canonical signalling
KW  - endocytosis
KW  - desensitization
KW  - internalization
KW  - casein kinase
N2  - Arrestins were originally identified as negative regulators of G protein-coupled receptor signaling. Recently, their diverse functions in intracellular signaling pathways as scaffold and signaling intermediate emerged providing mechanisms for achieving signal specificity and to attack for pharmacological intervention. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signaling. WNTs are secreted lipoglycoproteins acting through the seven transmembrane spanning receptors of the FZD family. During the last years it became evident that beta-arrestins are required for cellular communication by means of WNTs and FZDs both in cellular systems as well as in vivo. Although the overall importance of arrestin for WNT/FZD signaling remains still obscure, interaction with the central phosphoprotein disheveled and the endocytic machinery implicate beta-arrestin as a determinator of WNT signaling specificity, mediator of WNT/FZD desensitization and regulator of signaling compartmentation.
ER  -

SCHULTE, Gunnar, Alexandra SCHAMBONY and Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?). \textit{British Journal of Pharmacology}. 2010, vol.~159, No~5, p.~1051-8, 8 pp. ISSN~1476-5381.

Detailed Information on Publication Record