SCHULTE, Gunnar, Alexandra SCHAMBONY and Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?). British Journal of Pharmacology. 2010, vol. 159, No 5, p. 1051-8, 8 pp. ISSN 1476-5381. |
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@article{900948, author = {Schulte, Gunnar and Schambony, Alexandra and Bryja, Vitezslav}, article_number = {5}, keywords = {Dishevelled; RYK; ROR; b-catenin; canonical signalling; non-canonical signalling; endocytosis; desensitization; internalization; casein kinase}, language = {eng}, issn = {1476-5381}, journal = {British Journal of Pharmacology}, title = {b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?}, volume = {159}, year = {2010} }
TY - JOUR ID - 900948 AU - Schulte, Gunnar - Schambony, Alexandra - Bryja, Vitezslav PY - 2010 TI - b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? JF - British Journal of Pharmacology VL - 159 IS - 5 SP - 1051-8 EP - 1051-8 SN - 14765381 KW - Dishevelled KW - RYK KW - ROR KW - b-catenin KW - canonical signalling KW - non-canonical signalling KW - endocytosis KW - desensitization KW - internalization KW - casein kinase N2 - Arrestins were originally identified as negative regulators of G protein-coupled receptor signaling. Recently, their diverse functions in intracellular signaling pathways as scaffold and signaling intermediate emerged providing mechanisms for achieving signal specificity and to attack for pharmacological intervention. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signaling. WNTs are secreted lipoglycoproteins acting through the seven transmembrane spanning receptors of the FZD family. During the last years it became evident that beta-arrestins are required for cellular communication by means of WNTs and FZDs both in cellular systems as well as in vivo. Although the overall importance of arrestin for WNT/FZD signaling remains still obscure, interaction with the central phosphoprotein disheveled and the endocytic machinery implicate beta-arrestin as a determinator of WNT signaling specificity, mediator of WNT/FZD desensitization and regulator of signaling compartmentation. ER -
SCHULTE, Gunnar, Alexandra SCHAMBONY and Vitezslav BRYJA. b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (b-arrestins: scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?). \textit{British Journal of Pharmacology}. 2010, vol.~159, No~5, p.~1051-8, 8 pp. ISSN~1476-5381.
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