Detailed Information on Publication Record
2010
Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2
WITTE, Florian, Ondřej BERNATÍK, Katharina KIRCHNER, Jan MAŠEK, Annika MAHL et. al.Basic information
Original name
Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2
Authors
WITTE, Florian (276 Germany), Ondřej BERNATÍK (203 Czech Republic, guarantor, belonging to the institution), Katharina KIRCHNER (276 Germany), Jan MAŠEK (203 Czech Republic, belonging to the institution), Annika MAHL (276 Germany), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), Stefan MUNDLOS (276 Germany), Alexandra SCHAMBONY (276 Germany), Vítězslav BRYJA (203 Czech Republic, belonging to the institution) and Sigmar STRICKER (276 Germany)
Edition
FASEB JOURNAL, 2010, 0892-6638
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
Genetics and molecular biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 6.515
RIV identification code
RIV/00216224:14310/10:00049637
Organization unit
Faculty of Science
UT WoS
000279343600028
Keywords in English
Wnt/beta-catenin signaling; casein kinase; Ror2
Změněno: 20/4/2012 14:49, Ing. Zdeňka Rašková
Abstract
V originále
Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.
Links
| GA204/09/0498, research and development project |
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| GD204/09/H058, research and development project |
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| MSM0021622430, plan (intention) |
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