Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2

WITTE, Florian, Ondřej BERNATÍK, Katharina KIRCHNER, Jan MAŠEK, Annika MAHL, Pavel KREJČÍ, Stefan MUNDLOS, Alexandra SCHAMBONY, Vítězslav BRYJA and Sigmar STRICKER. Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2. FASEB JOURNAL. 2010, vol. 24, No 7, p. 2417-2426. ISSN 0892-6638. Available from: https://dx.doi.org/10.1096/fj.09-150615.

Basic information

• Original name: Negative regulation of Wnt signaling mediated by CK1- phosphorylated Dishevelled via Ror2
• Authors: WITTE, Florian (276 Germany), Ondřej BERNATÍK (203 Czech Republic, guarantor, belonging to the institution), Katharina KIRCHNER (276 Germany), Jan MAŠEK (203 Czech Republic, belonging to the institution), Annika MAHL (276 Germany), Pavel KREJČÍ (203 Czech Republic, belonging to the institution), Stefan MUNDLOS (276 Germany), Alexandra SCHAMBONY (276 Germany), Vítězslav BRYJA (203 Czech Republic, belonging to the institution) and Sigmar STRICKER (276 Germany).
• Edition: FASEB JOURNAL, 2010, 0892-6638.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: Genetics and molecular biology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 6.515
• RIV identification code: RIV/00216224:14310/10:00049637
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1096/fj.09-150615
• UT WoS: 000279343600028
• Keywords in English: Wnt/beta-catenin signaling; casein kinase; Ror2
• Tags: AKb, rivok, ZR

Abstract

Dishevelled (Dvl) is a multifunctional effector of different Wnt cascades. We provide evidence that Dvl phosphorylated by casein kinase 1 epsilon can bind atypical receptor kinase Ror2. We show that CK1-phosphorylated Dvl induced by both canonical and non-canonical Wnt ligands triggers negative feedback regulation in a Ror2-dependent manner.

Links

• GA204/09/0498, research and development project: Name: Dynamika proteinů interagujících s Dishevelled a jejich význam pro Wnt signálování

Investor: Czech Science Foundation, Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling

• GD204/09/H058, research and development project: Name: Mezibuněčná signalizace ve vývoji organismu a vzniku onemocnění

Investor: Czech Science Foundation, Intercellular signalling in development and disease

• MSM0021622430, plan (intention): Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie

Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies