J 2010

The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

KUBICEK, Karel, S. Kaspar GRIMM, Julien ORTS, Florenz SASSE, Teresa CARLOMAGNO et. al.

Basic information

Original name

The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

Authors

KUBICEK, Karel (203 Czech Republic, belonging to the institution), S. Kaspar GRIMM (276 Germany), Julien ORTS (756 Switzerland), Florenz SASSE (276 Germany) and Teresa CARLOMAGNO (380 Italy, guarantor)

Edition

Angewandte Chemie International Edition, Weinheim, Spolková republika Německo, Wiley-VCH Verlag GmbH & Co. 2010, 1433-7851

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 12.730

RIV identification code

RIV/00216224:14310/10:00044991

Organization unit

Faculty of Science

UT WoS

000279743200023

Keywords in English

conformation analysis;cytotoxicity;microtubules;NMR spectroscopy;tubulysin

Tags

International impact, Reviewed
Změněno: 27/1/2011 15:37, doc. Mgr. Karel Kubíček, PhD.

Abstract

V originále

Bound to be active: The solution structure of tubulin-bound tubulysin A is determined from transferred NOE data (see picture; blue N, red O, yellow S, green C), and this bioactive conformation is compared to the unbound conformation. The binding site on tubulin is examined on the basis of the interligand NOEs observed between epothilone A and tubulysin A in the presence of tubulin.

Links

MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
MUNI/A/1046/2009, interní kód MU
Name: Biofyzikální výzkum struktur a funkcí biomolekul (Acronym: BVSFB)
Investor: Masaryk University, Category A