The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ and Pavel ŠEVČÍK. The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart. Physiological Research. Praha: Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, vol. 59, Suppl. 1, p. S65-S69, 5 pp. ISSN 0862-8408.

Basic information

• Original name: The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart
• Authors: KŘIKAVA, Ivo (203 Czech Republic, guarantor), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Petr ŠTOURAČ (203 Czech Republic), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Pavel ŠEVČÍK (203 Czech Republic, belonging to the institution).
• Edition: Physiological Research, Praha, Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, 0862-8408.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.646
• RIV identification code: RIV/00216224:14110/10:00045035
• Organization unit: Faculty of Medicine
• UT WoS: 000279049100010
• Keywords (in Czech): Bupivakain;Lidokain;Izolované srdce potkana;Kardiotoxicita;Trvání QRS
• Keywords in English: Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration
• Tags: International impact, Reviewed

Abstract

Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L (12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.

Links

• GA102/07/1473, research and development project: Name: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Czech Science Foundation

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases