The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity
in the Isolated Rat Heart

J 2010

The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ, Pavel ŠEVČÍK et. al.

Basic information

Original name

The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

Authors

KŘIKAVA, Ivo (203 Czech Republic, guarantor), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Petr ŠTOURAČ (203 Czech Republic), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Pavel ŠEVČÍK (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Praha, Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.646

RIV identification code

RIV/00216224:14110/10:00045035

Organization unit

Faculty of Medicine

UT WoS

000279049100010

Keywords (in Czech)

Bupivakain;Lidokain;Izolované srdce potkana;Kardiotoxicita;Trvání QRS

Keywords in English

Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration

Abstract

V originále

Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L (12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.

Links

GA102/07/1473, research and development project

Name: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Czech Science Foundation

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

Citovat

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ and Pavel ŠEVČÍK. The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart. Physiological Research. Praha: Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, vol. 59, Suppl. 1, p. S65-S69, 5 pp. ISSN 0862-8408.

@article{902214,
   author = {Křikava, Ivo and Jarkovský, Jiří and Štourač, Petr and Nováková, Marie and Ševčík, Pavel},
   article_location = {Praha},
   article_number = {Suppl. 1},
   keywords = {Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart},
   url = {http://www.biomed.cas.cz/physiolres/2010/S1_10.htm},
   volume = {59},
   year = {2010}
}

TY  - JOUR
ID  - 902214
AU  - Křikava, Ivo - Jarkovský, Jiří - Štourač, Petr - Nováková, Marie - Ševčík, Pavel
PY  - 2010
TI  - The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart
JF  - Physiological Research
VL  - 59
IS  - Suppl. 1
SP  - S65-S69
EP  - S65-S69
PB  - Institute of Physiology,Academy of Sciences of the Czech Republic
SN  - 08628408
KW  - Bupivacaine;Lidocaine;Isolated rat heart;Cardiotoxicity;QRS duration
UR  - http://www.biomed.cas.cz/physiolres/2010/S1_10.htm
N2  - Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L (12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.
ER  -

KŘIKAVA, Ivo, Jiří JARKOVSKÝ, Petr ŠTOURAČ, Marie NOVÁKOVÁ and Pavel ŠEVČÍK. The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart. \textit{Physiological Research}. Praha: Institute of Physiology,Academy of Sciences of the Czech Republic, 2010, vol.~59, Suppl. 1, p.~S65-S69, 5 pp. ISSN~0862-8408.

Detailed Information on Publication Record