Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin

LAMEIGNERE, Emilie, Tze Chieh SHIAO, Rene ROY, Michaela WIMMEROVÁ, Fréderic DUBREUIL, Annabelle VARROT and Anne IMBERTY. Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin. Glycobiology. Oxford: Oxford University Press, 2010, vol. 20, No 1, p. 87-98. ISSN 0959-6658. Available from: https://dx.doi.org/10.1093/glycob/cwp151.

Basic information

• Original name: Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin
• Name in Czech: Strukturní základ afinity lektinu BC2L-A z Burkholderia cenocepacia k oligomannosidům a jejich analogům
• Authors: LAMEIGNERE, Emilie (250 France), Tze Chieh SHIAO (124 Canada), Rene ROY (124 Canada), Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution), Fréderic DUBREUIL (250 France), Annabelle VARROT (250 France) and Anne IMBERTY (250 France).
• Edition: Glycobiology, Oxford, Oxford University Press, 2010, 0959-6658.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10610 Biophysics
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.791
• RIV identification code: RIV/00216224:14310/10:00073364
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1093/glycob/cwp151
• UT WoS: 000272179800009
• Keywords (in Czech): bakteriální lektin;Burkholderia cenocepacia;mannosa;oligosacharidy
• Keywords in English: bacterial lectin;Burkholderia cenocepacia;mannose;oligosaccharides
• Tags: AKR, rivok
• Tags: International impact, Reviewed

Abstract

The disaccharides and the trisaccharide,Man1-3(Man1-6)Man were tested by titration microcalorimetry in order to evaluate their affinity for BC2L-A in solution and to characterize the thermodynamics of the binding. Oligomannose analogs presenting two mannoside residues separated by either flexible or rigid spacer where also tested.

Abstract (in Czech)

Disacharidy a trimannosid Man1-3(Man1-6)Man, byly testovany pomoci titracni mikrokalorimetrie a ukazaly strukturní základ afinity lektinu BC2L-A z Burkholderia cenocepacia k oligomannosidům a jejich analogům

Links

• GA303/09/1168, research and development project: Name: Lektiny z lidských patogenů - struktura, funkce, inženýrství

Investor: Czech Science Foundation, Lectins from human pathogens - structure, function, engineering

• LC06030, research and development project: Name: Biomolekulární centrum

Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre

• ME08008, research and development project: Name: Návrh antibakteriálních a antivirových léků na bázi cukrů a glykomimetik

Investor: Ministry of Education, Youth and Sports of the CR, Design of Carbohydrates and Glycomimetics as Antibacterial and Antiviral Drugs, Research and Development Programme KONTAKT (ME)

• MSM0021622413, plan (intention): Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment