J 2010

Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity

JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ et. al.

Basic information

Original name

Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity

Name in Czech

Asociace polymorfismu A1166C v genu pro AT1 receptor s citlivostí baroreflexu

Authors

JÍRA, Miroslav (203 Czech Republic, belonging to the institution), Eva ZÁVODNÁ (203 Czech Republic, belonging to the institution), Nataša HONZÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution) and Bohumil FIŠER (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Praha, Institute of Physiology, Academy of Sci, 2010, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.646

RIV identification code

RIV/00216224:14110/10:00045098

Organization unit

Faculty of Medicine

UT WoS

000282054700005

Keywords in English

baroreflex sensitivity; angiotensin II type 1 receptor; polymorphism; spectral analysis

Tags

International impact, Reviewed
Změněno: 6/4/2011 11:05, MUDr. Mgr. Miroslav Jíra, Ph.D.

Abstract

ORIG CZ

V originále

Diminished baroreflex sensitivity is connected with hypertension, cardiac failure and presents a risk factor for sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity in man. We found a significant association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity.

In Czech

Snížená citlivost baroreflexu je spojena s hypertenzí, srdečním selháním a představuje riziko náhlé srdeční smrti u pacientů po infarktu myokardu. Cílem studie bylo hodnotit asociaci polymorfismu A1166C v genu pro receptor pro angiotensin II (AT1R) s citlivostí baroreflexu u člověka. Byla nalezena signifikantní asociace tohoto polymorfismu s citlivostí baroreflex. Homozygoti pro méně četnou alelu měli sníženou citlivost baroreflexu.

Links

MSM0021622402, plan (intention)
Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
Displayed: 4/11/2024 06:41