Association of A1166C Polymorphism in AT(1) Receptor Gene with
Baroreflex Sensitivity

J 2010

Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity

JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ et. al.

Basic information

Original name

Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity

Name in Czech

Asociace polymorfismu A1166C v genu pro AT1 receptor s citlivostí baroreflexu

Authors

JÍRA, Miroslav (203 Czech Republic, belonging to the institution), Eva ZÁVODNÁ (203 Czech Republic, belonging to the institution), Nataša HONZÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution) and Bohumil FIŠER (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Praha, Institute of Physiology, Academy of Sci, 2010, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.646

RIV identification code

RIV/00216224:14110/10:00045098

Organization unit

Faculty of Medicine

UT WoS

000282054700005

Keywords in English

baroreflex sensitivity; angiotensin II type 1 receptor; polymorphism; spectral analysis

Abstract

ORIG CZ

V originále

Diminished baroreflex sensitivity is connected with hypertension, cardiac failure and presents a risk factor for sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity in man. We found a significant association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity.

In Czech

Snížená citlivost baroreflexu je spojena s hypertenzí, srdečním selháním a představuje riziko náhlé srdeční smrti u pacientů po infarktu myokardu. Cílem studie bylo hodnotit asociaci polymorfismu A1166C v genu pro receptor pro angiotensin II (AT1R) s citlivostí baroreflexu u člověka. Byla nalezena signifikantní asociace tohoto polymorfismu s citlivostí baroreflex. Homozygoti pro méně četnou alelu měli sníženou citlivost baroreflexu.

Links

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

Citovat

JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Bohumil FIŠER. Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity. Physiological Research. Praha: Institute of Physiology, Academy of Sci, 2010, vol. 59, No 4, p. 517-528. ISSN 0862-8408.

@article{903062,
   author = {Jíra, Miroslav and Závodná, Eva and Honzíková, Nataša and Nováková, Zuzana and Vašků, Anna and Izakovičová Hollá, Lydie and Fišer, Bohumil},
   article_location = {Praha},
   article_number = {4},
   keywords = {baroreflex sensitivity; angiotensin II type 1 receptor; polymorphism; spectral analysis},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity},
   url = {http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=X1EL3PjGbGJMeHdJIdi&page=1&doc=2},
   volume = {59},
   year = {2010}
}

TY  - JOUR
ID  - 903062
AU  - Jíra, Miroslav - Závodná, Eva - Honzíková, Nataša - Nováková, Zuzana - Vašků, Anna - Izakovičová Hollá, Lydie - Fišer, Bohumil
PY  - 2010
TI  - Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity
JF  - Physiological Research
VL  - 59
IS  - 4
SP  - 517-528
EP  - 517-528
PB  - Institute of Physiology, Academy of Sci
SN  - 08628408
KW  - baroreflex sensitivity
KW  - angiotensin II type 1 receptor
KW  - polymorphism
KW  - spectral analysis
UR  - http://apps.isiknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=X1EL3PjGbGJMeHdJIdi&page=1&doc=2
N2  - Diminished baroreflex sensitivity is connected with hypertension, cardiac failure and presents a risk factor for sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity in man. We found a significant association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity.
ER  -

JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Bohumil FIŠER. Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity. \textit{Physiological Research}. Praha: Institute of Physiology, Academy of Sci, 2010, vol.~59, No~4, p.~517-528. ISSN~0862-8408.

Detailed Information on Publication Record