JÍRA, Miroslav, Eva ZÁVODNÁ, Nataša HONZÍKOVÁ, Zuzana NOVÁKOVÁ, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ and Bohumil FIŠER. Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity. Physiological Research. Praha: Institute of Physiology, Academy of Sci, 2010, vol. 59, No 4, p. 517-528. ISSN 0862-8408.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Association of A1166C Polymorphism in AT(1) Receptor Gene with Baroreflex Sensitivity
Name in Czech Asociace polymorfismu A1166C v genu pro AT1 receptor s citlivostí baroreflexu
Authors JÍRA, Miroslav (203 Czech Republic, belonging to the institution), Eva ZÁVODNÁ (203 Czech Republic, belonging to the institution), Nataša HONZÍKOVÁ (203 Czech Republic, guarantor, belonging to the institution), Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, belonging to the institution) and Bohumil FIŠER (203 Czech Republic, belonging to the institution).
Edition Physiological Research, Praha, Institute of Physiology, Academy of Sci, 2010, 0862-8408.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.646
RIV identification code RIV/00216224:14110/10:00045098
Organization unit Faculty of Medicine
UT WoS 000282054700005
Keywords in English baroreflex sensitivity; angiotensin II type 1 receptor; polymorphism; spectral analysis
Tags International impact, Reviewed
Changed by Changed by: MUDr. Mgr. Miroslav Jíra, Ph.D., učo 12198. Changed: 6/4/2011 11:05.
Abstract
Diminished baroreflex sensitivity is connected with hypertension, cardiac failure and presents a risk factor for sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT(1)R) gene with baroreflex sensitivity in man. We found a significant association of A1166C polymorphism in AT(1) receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity.
Abstract (in Czech)
Snížená citlivost baroreflexu je spojena s hypertenzí, srdečním selháním a představuje riziko náhlé srdeční smrti u pacientů po infarktu myokardu. Cílem studie bylo hodnotit asociaci polymorfismu A1166C v genu pro receptor pro angiotensin II (AT1R) s citlivostí baroreflexu u člověka. Byla nalezena signifikantní asociace tohoto polymorfismu s citlivostí baroreflex. Homozygoti pro méně četnou alelu měli sníženou citlivost baroreflexu.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
PrintDisplayed: 6/7/2024 16:42