BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dana OHLÍDALOVÁ, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes. Acta Physiologica. Oxford: Blackwell Publishing, 2010, vol. 200, No 4, p. 301-314. ISSN 1748-1708. Available from: https://dx.doi.org/10.1111/j.1748-1716.2010.02162.x. |
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@article{906829, author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Ohlídalová, Dana and Jansová, Dagmar and Šimurdová, Milena and Šimurda, Jiří}, article_location = {Oxford}, article_number = {4}, doi = {http://dx.doi.org/10.1111/j.1748-1716.2010.02162.x}, keywords = {ethanol; action potential; sodium current; calcium current; transient outward potassium current; rat ventricular myocytes}, language = {eng}, issn = {1748-1708}, journal = {Acta Physiologica}, title = {Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes}, volume = {200}, year = {2010} }
TY - JOUR ID - 906829 AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Ohlídalová, Dana - Jansová, Dagmar - Šimurdová, Milena - Šimurda, Jiří PY - 2010 TI - Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes JF - Acta Physiologica VL - 200 IS - 4 SP - 301-314 EP - 301-314 PB - Blackwell Publishing SN - 17481708 KW - ethanol KW - action potential KW - sodium current KW - calcium current KW - transient outward potassium current KW - rat ventricular myocytes N2 - Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile). ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dana OHLÍDALOVÁ, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes. \textit{Acta Physiologica}. Oxford: Blackwell Publishing, 2010, vol.~200, No~4, p.~301-314. ISSN~1748-1708. Available from: https://dx.doi.org/10.1111/j.1748-1716.2010.02162.x.
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