Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dana OHLÍDALOVÁ, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes. Acta Physiologica. Oxford: Blackwell Publishing, 2010, vol. 200, No 4, p. 301-314. ISSN 1748-1708. Available from: https://dx.doi.org/10.1111/j.1748-1716.2010.02162.x.

Basic information

• Original name: Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes
• Name in Czech: Vliv ethanolu na akční napětí a iontové membránové proudy u komorových srdečních buněk potkana
• Authors: BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic), Dana OHLÍDALOVÁ (203 Czech Republic), Dagmar JANSOVÁ (203 Czech Republic, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution).
• Edition: Acta Physiologica, Oxford, Blackwell Publishing, 2010, 1748-1708.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.138
• RIV identification code: RIV/00216224:14110/10:00051512
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/j.1748-1716.2010.02162.x
• UT WoS: 000284810500002
• Keywords (in Czech): ethanol; akční napětí; sodíkový proud; kalciový proud; přechodný draslíkový proud z buňky; komorové srdeční buňky potkana
• Keywords in English: ethanol; action potential; sodium current; calcium current; transient outward potassium current; rat ventricular myocytes
• Tags: International impact, Reviewed

Abstract

Ethanol reversibly decelerated the upstroke velocity and decreased AP amplitude and duration at 0.2 and 3 Hz. The fast sodium current INa, L-type calcium current ICa and transient outward potassium current Ito were reversibly inhibited in a concentration-dependent manner.As a consequence of marked differences in nH, sensitivity of the currents to ethanol at 10%-inhibition decreases in the following order: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile).

Abstract (in Czech)

Ethanol vratně zpomaloval maximální rychlost depolarizace akčního napětí (AN) a snižoval jeho amplitudu a zkracoval trvání AN. Blokoval INa, ICa a Ito. Vzhledem k velkým rozdílům v nH klesala citlivost proudů k 10%-ní inhibici ethanolem v tomto pořadí: ICa (75 mM, 3.5 promile), Ito (170 mM, 7.8 promile) and INa (220 mM, 10.1 promile).

Links

• MSM0021622402, plan (intention): Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases