Source-Based Morphometry of Gray Matter Volume in Men With First-Episode Schizophrenia

KAŠPÁREK, Tomáš, Radek MAREČEK and Daniel SCHWARZ. Source-Based Morphometry of Gray Matter Volume in Men With First-Episode Schizophrenia. Human Brain Mapping. USA, 2010, vol. 31, No 2, p. 300-310. ISSN 1065-9471.

Basic information

• Original name: Source-Based Morphometry of Gray Matter Volume in Men With First-Episode Schizophrenia
• Name in Czech: Source-based morfometrie Gray matter hlasitosti u mužů s první epizodou schizofrenie
• Authors: KAŠPÁREK, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution) and Daniel SCHWARZ (203 Czech Republic, belonging to the institution).
• Edition: Human Brain Mapping, USA, 2010, 1065-9471.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30000 3. Medical and Health Sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 5.107
• RIV identification code: RIV/00216224:14110/10:00045364
• Organization unit: Faculty of Medicine
• UT WoS: 000274460900012
• Keywords (in Czech): Source based morfometrie; sluchové halucinace; struktura mozku; kognitivní dysfunkce,
• Keywords in English: voxel besed morphometry; dorsolateral prefrontal cortex; cerebral blood flow; grey mattter; frontotemporal connectivity; auditory hallucinations; cognitive dysmetria; brain structure; sex differences

Abstract

There is a lot of variability between the results of studies reporting the pattern of gray matter volume changes in schizophrenia. Methodological issues may play an important role in this heterogeneity. The aim of the present study was to replicate the better performance of multivariate source-based morphometry over the mass univariate approach. Experimental design: Voxel based morphnometry of Jacobian modulated gray matter volume episode schizophrenia patients and healthy controls. Results: Using SBM we were able to find a significant reduction of gray matter volume in fronto temporo cerebellar areas whereas no significant results were obtained using voxel based morphometry.

Abstract (in Czech)

Cílem této studie bylo replikovat lepší výkon vícerozměrných na zdroji založené morfometrie nad množstvím jednorozměrných přístupů. Experimentální design: Voxel vychází z morphnometru Jakobiánu modulovaného objemu šedé hmoty u pacientů s první epizodou schizofrenie a zdravých kontrol. Výsledky: Pomocí SBM jsme byli schopni najít významné snížení objemu šedé hmoty v oblasti fronto temporo mozečku. Žádné významné výsledky nebyly získány pomocí voxel based metody založené na morfometrii.

Links

• MSM0021622404, plan (intention): Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS

Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.