The differences between small molecule crystallography and crystallography of proteins

DEMO, Gabriel, Necas MAREK and Michaela WIMMEROVÁ. The differences between small molecule crystallography and crystallography of proteins. In 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13). 2010.

Basic information

• Original name: The differences between small molecule crystallography and crystallography of proteins
• Name in Czech: Rozdíly mezi krystalografií malých molekul a krystalografií proteinů
• Authors: DEMO, Gabriel (703 Slovakia, belonging to the institution), Necas MAREK (203 Czech Republic, belonging to the institution) and Michaela WIMMEROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: 13th International Conference on the Crystallization of Biological Macromolecules (ICCBM13), 2010.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10610 Biophysics
• Country of publisher: Ireland
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/10:00045651
• Organization unit: Faculty of Science
• Keywords (in Czech): krystalizace; malé molekuly; proteiny; zběr dat; určování struktury
• Keywords in English: crystallization; small molecules; proteins; collection of data; determination of structure

Abstract

Differences between small molecule crystallography and crystallography of proteins were presented. The first part showed the crystallization process. Second part was inscribed to the instrumentation and the differences by used sources of X-ray, measurment dependence of time and also the enviroment used for the measured crystal. Finally, the last part was devoted to differences in used computational methods. The solution of phase problem for small molecules (Direct methods, Patterson's map) and for the proteins(Molecular replacement, Method of heavy atoms).

Abstract (in Czech)

Rozdíly mezi krystalografií malých molekul a proteinů byly prezentovány. První část poukázala na krystalizační proces. Druhá část se věnovala rozdíly v přístrojovém zařízení, v zdroji záření, v závislosti na čase a také systémovému uspořádaní měřeného krystalu. Poslední část říka o rozdílech ve výpočtové části. Popisuje řešení fázového problému u malých molekul a u proteinů.

Links

• GAP207/10/0321, research and development project: Name: Enzymy metabolismu mannosidů v přípravě N-acetyl-mannosaminových struktur

Investor: Czech Science Foundation

• MSM0021622413, plan (intention): Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment