A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome

VAŠÍKOVÁ, Alžbeta; Monika BELIČKOVÁ; Eva BUDINSKÁ and Jaroslav ČERMÁK. A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome. Leukemia Research. 2010, vol. 34, No 12, p. 1566-1572. ISSN 0145-2126.

Basic information

Original name

A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome

Authors

VAŠÍKOVÁ, Alžbeta; Monika BELIČKOVÁ; Eva BUDINSKÁ and Jaroslav ČERMÁK

Edition

Leukemia Research, 2010, 0145-2126

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Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 2.555

RIV identification code

RIV/00216224:14110/10:00051564

Organization unit

Faculty of Medicine

UT WoS

000283845900019

Keywords in English

Myelodysplastic syndrome Acute myeloid leukemia Gene expression profiling Microarray CD34+ cells

Tags

International impact, Reviewed

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Abstract

In the original language

Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS.