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@article{911162, author = {Vašíková, Alžbeta and Beličková, Monika and Budinská, Eva and Čermák, Jaroslav}, article_number = {12}, keywords = {Myelodysplastic syndrome Acute myeloid leukemia Gene expression profiling Microarray CD34+ cells}, language = {eng}, issn = {0145-2126}, journal = {Leukemia Research}, title = {A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome}, volume = {34}, year = {2010} }
TY - JOUR ID - 911162 AU - Vašíková, Alžbeta - Beličková, Monika - Budinská, Eva - Čermák, Jaroslav PY - 2010 TI - A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome JF - Leukemia Research VL - 34 IS - 12 SP - 1566-1572 EP - 1566-1572 SN - 01452126 KW - Myelodysplastic syndrome Acute myeloid leukemia Gene expression profiling Microarray CD34+ cells N2 - Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS. ER -
VAŠÍKOVÁ, Alžbeta, Monika BELIČKOVÁ, Eva BUDINSKÁ and Jaroslav ČERMÁK. A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome. \textit{Leukemia Research}. 2010, vol.~34, No~12, p.~1566-1572. ISSN~0145-2126.
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