VAŠÍKOVÁ, Alžbeta, Monika BELIČKOVÁ, Eva BUDINSKÁ and Jaroslav ČERMÁK. A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome. Leukemia Research. 2010, vol. 34, No 12, p. 1566-1572. ISSN 0145-2126.
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Basic information
Original name A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome
Authors VAŠÍKOVÁ, Alžbeta (203 Czech Republic), Monika BELIČKOVÁ (203 Czech Republic), Eva BUDINSKÁ (703 Slovakia, belonging to the institution) and Jaroslav ČERMÁK (203 Czech Republic, guarantor).
Edition Leukemia Research, 2010, 0145-2126.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 2.555
RIV identification code RIV/00216224:14110/10:00051564
Organization unit Faculty of Medicine
UT WoS 000283845900019
Keywords in English Myelodysplastic syndrome Acute myeloid leukemia Gene expression profiling Microarray CD34+ cells
Tags International impact, Reviewed
Changed by Changed by: Mgr. Eva Budinská, Ph.D., učo 40822. Changed: 11/5/2011 14:14.
Abstract
Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS.
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