J 2010

Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling

WABNIK, Krzysztof, Jürgen KLEINE-VEHN, Jozef BALLA, Sauer MICHAEL, Satoshi NARAMOTO et. al.

Basic information

Original name

Emergence of tissue polarization from synergy of intracellular and extracellular auxin signaling

Name in Czech

Polarizace pletiv ze synergie auxinového signalingu vně a vevnitř buněk

Authors

WABNIK, Krzysztof (616 Poland), Jürgen KLEINE-VEHN (276 Germany), Jozef BALLA (703 Slovakia), Sauer MICHAEL (276 Germany), Satoshi NARAMOTO (392 Japan), Vilém REINÖHL (203 Czech Republic), Roeland MH MERKS (528 Netherlands), Willy GOVAERTS (56 Belgium) and Jiří FRIML (203 Czech Republic, guarantor, belonging to the institution)

Edition

Molecular systems biology, 2010, 1744-4292

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 9.667

RIV identification code

RIV/00216224:14310/10:00040635

Organization unit

Faculty of Science

UT WoS

000285930400003

Keywords (in Czech)

auxin; canalization; cell polarity; PIN proteins

Keywords in English

auxin; kanalizace; buněčná polarita; PIN proteiny
Změněno: 10/1/2011 13:33, Mgr. Gabriela Jalová

Abstract

ORIG CZ

V originále

Plant development is exceptionally flexible as manifested by its potential for organogenesis and regeneration, which are processes involving rearrangements of tissue polarities. Fundamental questions concern how individual cells can polarize in a coordinated manner to integrate into the multicellular context. In canalization models, the signaling molecule auxin acts as a polarizing cue, and feedback on the intercellular auxin flow is key for synchronized polarity rearrangements. We provide a novel mechanistic framework for canalization, based on up-to-date experimental data and minimal, biologically plausible assumptions. Our model combines the intracellular auxin signaling for expression of PINFORMED (PIN) auxin transporters and the theoretical postulation of extracellular auxin signaling for modulation of PIN subcellular dynamics. Computer simulations faithfully and robustly recapitulated the experimentally observed patterns of tissue polarity and asymmetric auxin distribution during formation and regeneration of vascular systems and during the competitive regulation of shoot branching by apical dominance. Additionally, our model generated new predictions that could be experimentally validated, highlighting a mechanistically conceivable explanation for the PIN polarization and canalization of the auxin flow in plants.

In Czech

Vývoj rostlin je velmi flexibilní a často při něm dochází k synchronizované reorganizaci buněčné polarity. Mechanizmus, který je za to zodpovědný není znám. Tento článek prezentuje matematický model, který ukazuje, že rostlinný hormon auxin je schopný polarizovat lokalizaci auxinových transporterů a tímto způsobem polarizovat rostlinná pletiva v průběhu mnoha vývojových procesů.

Links

IAA601630703, research and development project
Name: Identifikace molekulárních komponent a mechanizmu polárního směrování auxinových transportních proteinů rodiny PIN u Arabidopsis thaliana
Investor: Academy of Sciences of the Czech Republic, Identification of molecular components and the mechanism of polar targeting of PIN auxin transport proteins in Arabidopsis thaliana
LC06034, research and development project
Name: Regulace morfogeneze rostlinných buněk a orgánů
Investor: Ministry of Education, Youth and Sports of the CR, Regulation of morphogenesis of plant cells and organs