| NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ and Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. General Physioogy and Biophysics. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, vol. 29, No 4, p. 381-389. ISSN 0231-5882. |
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@article{911684,
author = {Nováková, Marie and Sedláková, Barbora and Sirová, Marta and Fialová, Kateřina and Križanová, Olga},
article_location = {Bratislava},
article_number = {4},
keywords = {haloperidol; sigma receptor; IP3 receptor},
language = {eng},
issn = {0231-5882},
journal = {General Physioogy and Biophysics},
title = {Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles},
volume = {29},
year = {2010}
}
TY - JOUR
ID - 911684
AU - Nováková, Marie - Sedláková, Barbora - Sirová, Marta - Fialová, Kateřina - Križanová, Olga
PY - 2010
TI - Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles
JF - General Physioogy and Biophysics
VL - 29
IS - 4
SP - 381-389
EP - 381-389
PB - INST OF MOLEC PHYSIOL GENETICS SLOVAK AC
SN - 02315882
KW - haloperidol
KW - sigma receptor
KW - IP3 receptor
N2 - Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles.
ER -
NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ and Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. \textit{General Physioogy and Biophysics}. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, vol.~29, No~4, p.~381-389. ISSN~0231-5882.
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