Haloperidol increases expression of the inositol
1,4,5-trisphosphate receptors in rat cardiac atria, but not in
vnetricles

J 2010

Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles

NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ, Olga KRIŽANOVÁ et. al.

Basic information

Original name

Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles

Authors

NOVÁKOVÁ, Marie (203 Czech Republic, guarantor), Barbora SEDLÁKOVÁ (703 Slovakia), Marta SIROVÁ (703 Slovakia), Kateřina FIALOVÁ (203 Czech Republic) and Olga KRIŽANOVÁ (703 Slovakia)

Edition

General Physioogy and Biophysics, Bratislava, INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, 0231-5882

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.146

RIV identification code

RIV/00216224:14110/10:00045742

Organization unit

Faculty of Medicine

UT WoS

000286693400007

Keywords (in Czech)

haloperidol; sigma receptor; IP3 receptor

Keywords in English

haloperidol; sigma receptor; IP3 receptor

Abstract

V originále

Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles.

Links

GA102/07/1473, research and development project

Name: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací

Investor: Czech Science Foundation

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

Citovat

NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ and Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. General Physioogy and Biophysics. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, vol. 29, No 4, p. 381-389. ISSN 0231-5882.

@article{911684,
   author = {Nováková, Marie and Sedláková, Barbora and Sirová, Marta and Fialová, Kateřina and Križanová, Olga},
   article_location = {Bratislava},
   article_number = {4},
   keywords = {haloperidol; sigma receptor; IP3 receptor},
   language = {eng},
   issn = {0231-5882},
   journal = {General Physioogy and Biophysics},
   title = {Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles},
   volume = {29},
   year = {2010}
}

TY  - JOUR
ID  - 911684
AU  - Nováková, Marie - Sedláková, Barbora - Sirová, Marta - Fialová, Kateřina - Križanová, Olga
PY  - 2010
TI  - Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles
JF  - General Physioogy and Biophysics
VL  - 29
IS  - 4
SP  - 381-389
EP  - 381-389
PB  - INST OF MOLEC PHYSIOL GENETICS SLOVAK AC
SN  - 02315882
KW  - haloperidol
KW  - sigma receptor
KW  - IP3 receptor
N2  - Numerous ligands of sigma receptors are known to prolong the QT interval and therefore to cause a variety of arrhythmias. High affinity binding sites for the prototypical sigma ligand haloperidol were found in membranes of cardiac myocytes from adult rats. Activation of sigma 1 receptor leads to a release of calcium from the endoplasmic reticulum that follows increased synthesis of inositol 1,4,5-trisphosphate (IP3). We studied the effect of long-term haloperidol treatment on the expression of sigma 1 receptors, IP3 receptors of type 1 and 2 in the individual parts of the rat heart, in isolated rat cardiomyocytes and in PC12 cells. We have found that prolonged treatment with haloperidol significantly increased mRNA levels of sigma 1 receptors in both atria and ventricles. Sigma 1 receptor s mRNA was increased also in isolated cardiomyocytes. Haloperidol treatment affects the expression of IP3 receptors of type 1 and 2 in cardiac atria, but not in cardiac ventricles.
ER  -

NOVÁKOVÁ, Marie, Barbora SEDLÁKOVÁ, Marta SIROVÁ, Kateřina FIALOVÁ and Olga KRIŽANOVÁ. Haloperidol increases expression of the inositol 1,4,5-trisphosphate receptors in rat cardiac atria, but not in vnetricles. \textit{General Physioogy and Biophysics}. Bratislava: INST OF MOLEC PHYSIOL GENETICS SLOVAK AC, 2010, vol.~29, No~4, p.~381-389. ISSN~0231-5882.

Detailed Information on Publication Record